{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:07:49Z","timestamp":1788973669558,"version":"build-2803163510"},"reference-count":28,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100008209","name":"University at Buffalo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002784","name":"Canada Excellence Research Chairs, Government of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transitions often begin through weak precursor dynamics that reorganize a system before the dominant transformation becomes apparent, yet these early signatures can remain distributed and hidden within a single observable. Here, hollow microfluidic cantilevers resolve such onset behavior by tracking the resonance trajectory of picoliter-confined samples during controlled slow heating. Using DNA premelting as a model system, we identify a lower-temperature spectral departure that persists across three duplex sequence backgrounds before the main melting response. Projection of the same spectra into buffer-referenced response coordinates enhances the contrast of this onset-associated change without replacing the primary spectral evidence. The resulting operational marker identifies when weak local fluctuations first become mechanically consequential in the confined fluid system. More broadly, the approach detects the transition onset as a persistent reorganization of a measured trajectory rather than a large scalar signal.<\/jats:p>","DOI":"10.1021\/acs.nanolett.6c03366","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:01:41Z","timestamp":1786525301000},"page":"11930-11936","source":"Crossref","is-referenced-by-count":0,"title":["Nanomechanical\nDetection of Transition Onset"],"prefix":"10.1021","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6292-4928","authenticated-orcid":true,"given":"Arindam","family":"Phani","sequence":"first","affiliation":[{"name":"University of Calgary , , 2500 University Drive NW , , ,","place":["Calgary, Alberta, Canada, T2N 1N4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Finot","sequence":"additional","affiliation":[{"name":"Universite\u0301 Bourgogne Europe , , 9 avenue Alain Savary, BP 47870 , ,","place":["Dijon Cedex, France, 21078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-1181","authenticated-orcid":true,"given":"Thomas","family":"Thundat","sequence":"additional","affiliation":[{"name":"University at Buffalo, The State University of New York , , 308 Furnas Hall, 215 Mary Talbert Way , , ,","place":["Buffalo, New York, United States, 14260-4200"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"2026090911331867700_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stlm.2024.100159","article-title":"A comprehensive review on hydrogel-based\nbio-ink development for tissue engineering scaffolds using 3D printing","volume":"15","author":"Gogoi","year":"2024","journal-title":"Annals of 3D Printed Medicine"},{"key":"2026090911331867700_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2024.112864","article-title":"3D-bioprinting\nof self-healing hydrogels","volume":"209","author":"Karvinen","year":"2024","journal-title":"Eur. 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Lett."},{"key":"2026090911331867700_cit6","doi-asserted-by":"publisher","DOI":"10.1063\/1.5092333","article-title":"Thermomechanical\nresponses of microfluidic cantilever\ncapture DNA melting and properties of DNA premelting states using\npicoliters of DNA solution","volume":"114","author":"Jiang","year":"2019","journal-title":"Appl. Phys. Lett."},{"key":"2026090911331867700_cit7","doi-asserted-by":"publisher","first-page":"16339","DOI":"10.1073\/pnas.1312165110","article-title":"Relationship between\ndynamical entropy and energy dissipation far from thermodynamic equilibrium","volume":"110","author":"Green","year":"2013","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"2026090911331867700_cit8","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0370-1573(85)90060-2","article-title":"Thermal denaturation\nof DNA molecules: A comparison\nof theory with experiment","volume":"126","author":"Wartell","year":"1985","journal-title":"Phys. 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Raman signatures of premelting and\nmelting transitions of poly(dA)\u00b7poly(dT) and comparison with\npoly(dA-dT)\u00b7poly(dA-dT)","volume":"63","author":"Movileanu","year":"2002","journal-title":"Biopolymers"},{"key":"2026090911331867700_cit17","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1093\/nar\/gkx1285","article-title":"How does temperature\nimpact the conformation\nof single DNA molecules below melting temperature?","volume":"46","author":"Brunet","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2026090911331867700_cit18","doi-asserted-by":"publisher","first-page":"3967","DOI":"10.1063\/1.1150021","article-title":"Calibration of rectangular atomic\nforce microscope cantilevers","volume":"70","author":"Sader","year":"1999","journal-title":"Rev. Sci. 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