{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:49:16Z","timestamp":1781322556478,"version":"3.54.1"},"reference-count":21,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070060"],"award-info":[{"award-number":["32070060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41907105"],"award-info":[{"award-number":["41907105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2017YFD0201405"],"award-info":[{"award-number":["2017YFD0201405"]}]},{"name":"National Key R&D Program of China","award":["2019YFA0905700"],"award-info":[{"award-number":["2019YFA0905700"]}]},{"name":"Shandong Provincial Natural Science Foundation, China","award":["ZR2019JQ11"],"award-info":[{"award-number":["ZR2019JQ11"]}]},{"name":"Shandong Provincial Natural Science Foundation, China","award":["ZR2019ZD18"],"award-info":[{"award-number":["ZR2019ZD18"]}]},{"name":"Shandong Provincial Natural Science Foundation, China","award":["ZR2020QH345"],"award-info":[{"award-number":["ZR2020QH345"]}]},{"name":"Youth Interdiscipline Innovative Research Group","award":["2020QNQT009"],"award-info":[{"award-number":["2020QNQT009"]}]},{"name":"Fundamental Research Funds of Shandong University","award":["2019GN029"],"award-info":[{"award-number":["2019GN029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Lett."],"published-print":{"date-parts":[[2021,9,3]]},"DOI":"10.1021\/acs.orglett.1c02589","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T17:18:38Z","timestamp":1628875118000},"page":"6967-6971","source":"Crossref","is-referenced-by-count":22,"title":["Discovery of Polycyclic Macrolide Shuangdaolides by Heterologous Expression of a Cryptic <i>trans<\/i>-AT PKS Gene Cluster"],"prefix":"10.1021","volume":"23","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9656-6479","authenticated-orcid":true,"given":"Haibo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyao","family":"Shen","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Dai","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Yan","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoju","family":"Li","sequence":"additional","affiliation":[{"name":"Core Facilities for Life and Environmental Sciences, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmei","family":"Ren","sequence":"additional","affiliation":[{"name":"Core Facilities for Life and Environmental Sciences, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Sun","sequence":"additional","affiliation":[{"name":"Shenyang Sinochem Agrochemicals R&D Company Ltd., Shenyang, Liaoning 110021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-5201","authenticated-orcid":true,"given":"Ya-Jie","family":"Tang","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1356-3211","authenticated-orcid":true,"given":"Xiaoying","family":"Bian","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NP00125K"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1039\/C8NP00091C"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2183"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201402199"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.054"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00097"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00835"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw960"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2010.01.014"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1087"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1249"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2013.07.006"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511027112"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.5b00016"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c00847"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0313-7"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1342"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00478"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201500040"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/c2np20019h"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1110\/ps.051415905"}],"container-title":["Organic Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.1c02589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T19:27:47Z","timestamp":1682450867000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.1c02589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":21,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2021,9,3]]}},"alternative-id":["10.1021\/acs.orglett.1c02589"],"URL":"https:\/\/doi.org\/10.1021\/acs.orglett.1c02589","relation":{},"ISSN":["1523-7060","1523-7052"],"issn-type":[{"value":"1523-7060","type":"print"},{"value":"1523-7052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]}}}