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This reaction proceeds via 6-endo-dig cyclization and C\u00ad(sp2)\u2013O coupling using green H2O as the unique solvent and 5-bromopyrimidin-2-amine as the critical additive. Mechanistically, a unique Cu\u00ad(III)-acetylide probably is the key intermediate, which allows exclusive 6-endo-dig selectivity.<\/jats:p>","DOI":"10.1021\/acs.orglett.2c01654","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T09:00:32Z","timestamp":1655456432000},"page":"4569-4574","source":"Crossref","is-referenced-by-count":10,"title":["Copper-Catalyzed 6-\n                    <i>endo<\/i>\n                    -\n                    <i>dig<\/i>\n                    Cyclization\u2013Coupling of 2\u2011Bromoaryl Ketones and Terminal\nAlkynes toward Naphthyl Aryl Ethers in Water"],"prefix":"10.1021","volume":"24","author":[{"given":"Lebin","family":"Su","sequence":"first","affiliation":[{"name":"Hunan University , , ,","place":["Changsha, China, 410082"]},{"name":"Hunan First Normal University , , ,","place":["Changsha, China, 410205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Xie","sequence":"additional","affiliation":[{"name":"Hunan University , , ,","place":["Changsha, China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2161-1372","authenticated-orcid":true,"given":"Jianyu","family":"Dong","sequence":"additional","affiliation":[{"name":"Hunan First Normal University , , ,","place":["Changsha, China, 410205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neng","family":"Pan","sequence":"additional","affiliation":[{"name":"Hunan University , , ,","place":["Changsha, China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Feng","family":"Yin","sequence":"additional","affiliation":[{"name":"Hunan University , , ,","place":["Changsha, China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-8618","authenticated-orcid":true,"given":"Yongbo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hunan University , , ,","place":["Changsha, China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"2026081712170063900_cit1a","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1002\/(SICI)1521-3773(19990802)38:15&lt;2096::AID-ANIE2096&gt;3.0.CO;2-F","article-title":"Chemistry,\nBiology, and Medicine of the Glycopeptide Antibiotics","volume":"38","author":"Nicolaou","year":"1999","journal-title":"Angew. 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