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This method features operational simplicity, wide substrate scope, high efficiency, and good to excellent stereoselectivity. Notably, it represents the first example of catalytic enantioselective synthesis of C\u2013N atropisomers with the use of activated isocyanides.<\/jats:p>","DOI":"10.1021\/acs.orglett.2c01761","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T20:08:40Z","timestamp":1655755720000},"page":"4645-4649","source":"Crossref","is-referenced-by-count":36,"title":["Simultaneous Construction of C\u2013N Axial and\nCentral Chirality via Silver-Catalyzed Desymmetrizative [3 + 2] Cycloaddition\nof Prochiral N\u2011Aryl Maleimides with Activated Isocyanides"],"prefix":"10.1021","volume":"24","author":[{"given":"Sen","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang-Hong","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-1489","authenticated-orcid":true,"given":"Linghui","family":"Qian","sequence":"additional","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-4825","authenticated-orcid":true,"given":"Jia-Yu","family":"Liao","sequence":"additional","affiliation":[{"name":"Zhejiang University , , , ,","place":["Hangzhou, China, 310058"]},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"2026081712181357600_cit1a","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1002\/anie.200901719","article-title":"The Challenge\nof Atropisomerism in Drug Discovery","volume":"48","author":"Clayden","year":"2009","journal-title":"Angew.\nChem., Int. 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