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Stereochemical analysis of this strategic transformation provides insight on the impact of the directing group carbinol stereogenicity on the reaction efficiency and, in turn, permits the conversion of the minor isomer of the spiroketal precursor to the requisite congener for successful spiroketalization.<\/jats:p>","DOI":"10.1021\/acs.orglett.5b00595","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T14:59:29Z","timestamp":1428332369000},"page":"1898-1901","source":"Crossref","is-referenced-by-count":11,"title":["Synthesis of a C(1)\u2013C(23) Fragment for Spirastrellolide\nE: Development of a Mechanistic Rationale for Spiroketalization"],"prefix":"10.1021","volume":"17","author":[{"given":"Alexander","family":"Sokolsky","sequence":"first","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Cattoen","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Amos B.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"2026090309070269300_cit1","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1021\/ja0348602","volume":"125","author":"Williams","year":"2003","journal-title":"J. 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