{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:06:49Z","timestamp":1793704009174,"version":"4.5.1"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2102000"],"award-info":[{"award-number":["2021YFC2102000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJ222410163047"],"award-info":[{"award-number":["LJ222410163047"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171273"],"award-info":[{"award-number":["32171273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471322"],"award-info":[{"award-number":["32471322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Lett."],"published-print":{"date-parts":[[2025,3,28]]},"DOI":"10.1021\/acs.orglett.5c00685","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T17:34:13Z","timestamp":1742492053000},"page":"3031-3036","source":"Crossref","is-referenced-by-count":2,"title":["Asymmetric Synthesis of CF<sub>3<\/sub>-Substituted \u03b2-Hydroxyketones and 1,3-Diols by Engineered Ketoreductases"],"prefix":"10.1021","volume":"27","author":[{"given":"Yangyang","family":"Li","sequence":"first","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhe","family":"Yu","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenming","family":"Huang","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxue","family":"Zhu","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Lv","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"You","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biopharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9180-0550","authenticated-orcid":true,"given":"Bin","family":"Qin","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131943"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100166a"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00226-2"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(99)00102-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0737-x"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000972872.50738.0c"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00898"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01788"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC04556C"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702925"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201600812"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b06630"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2009.10.139"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200900582"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2004.04.022"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jo101519t"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1039\/b200474g"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-004-1837-6"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB02320G"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ol701810v"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202001110"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/D3OB00193H"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.10.007"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201600921"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.10.040"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507910112"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2014.05.008"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/op9002714"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201900424"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/B919115C"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.7b00194"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/op900272d"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.3068"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b00807"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b01552"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.08.033"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/chir.10040"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b03256"}],"container-title":["Organic Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.5c00685","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.5c00685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T10:00:45Z","timestamp":1743156045000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.5c00685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,3,28]]}},"alternative-id":["10.1021\/acs.orglett.5c00685"],"URL":"https:\/\/doi.org\/10.1021\/acs.orglett.5c00685","relation":{},"ISSN":["1523-7060","1523-7052"],"issn-type":[{"value":"1523-7060","type":"print"},{"value":"1523-7052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,20]]}}}