{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:59:07Z","timestamp":1792551547663,"version":"4.5.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211534"],"award-info":[{"award-number":["BK20211534"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271151"],"award-info":[{"award-number":["22271151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Lett."],"published-print":{"date-parts":[[2025,9,12]]},"DOI":"10.1021\/acs.orglett.5c03367","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T10:24:05Z","timestamp":1756722245000},"page":"10235-10240","source":"Crossref","is-referenced-by-count":3,"title":["Divergent Synthesis of <i>gem<\/i>-Difluoro-2-oxabicyclo[2.1.1]hexanes Enabled by 1,3-Oxygen Rearrangement"],"prefix":"10.1021","volume":"27","author":[{"given":"Mengyu","family":"Wu","sequence":"first","affiliation":[{"name":"Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, State Key Laboratory of Material-Oriented Chemical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Wang","sequence":"additional","affiliation":[{"name":"Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, State Key Laboratory of Material-Oriented Chemical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguan","family":"Wang","sequence":"additional","affiliation":[{"name":"Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, State Key Laboratory of Material-Oriented Chemical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4034-5698","authenticated-orcid":true,"given":"Chuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, State Key Laboratory of Material-Oriented Chemical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education","place":["Hangzhou, China"]},{"name":"Hangzhou Normal University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-6845","authenticated-orcid":true,"given":"Chao","family":"Feng","sequence":"additional","affiliation":[{"name":"Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering, State Key Laboratory of Material-Oriented Chemical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c00765"},{"key":"ref1\/cit1b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c01809"},{"key":"ref2\/cit2a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202106352"},{"key":"ref2\/cit2b","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700082"},{"key":"ref2\/cit2c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01215"},{"key":"ref2\/cit2d","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB02812E"},{"key":"ref2\/cit2e","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00370K"},{"key":"ref3\/cit3a","doi-asserted-by":"publisher","DOI":"10.1021\/jm901241e"},{"key":"ref3\/cit3b","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20347b"},{"key":"ref4\/cit4a","volume-title":"Drug Like Properties: Concepts, Structure, Design and Methods","author":"Kerns E. H.","year":"2008"},{"key":"ref4\/cit4b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01409"},{"key":"ref4\/cit4c","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.116"},{"key":"ref4\/cit4d","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2022-0188"},{"key":"ref5\/cit5a","doi-asserted-by":"publisher","DOI":"10.1039\/D0QO00460J"},{"key":"ref5\/cit5b","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c01900"},{"key":"ref5\/cit5c","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04636-x"},{"key":"ref5\/cit5d","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02976"},{"key":"ref5\/cit5e","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310066"},{"key":"ref5\/cit5f","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01135-y"},{"key":"ref5\/cit5g","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304771"},{"key":"ref5\/cit5h","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c14077"},{"key":"ref5\/cit5i","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c01506"},{"key":"ref6\/cit6a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202004183"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c03606"},{"key":"ref6\/cit6c","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC03083K"},{"key":"ref6\/cit6d","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c01557"},{"key":"ref7\/cit7a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204719"},{"key":"ref7\/cit7b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202305043"},{"key":"ref7\/cit7c","doi-asserted-by":"publisher","DOI":"10.1039\/D5SC02836A"},{"key":"ref8\/cit8a","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01222-0"},{"key":"ref8\/cit8b","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC06684G"},{"key":"ref8\/cit8c","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03542"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA08714K"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00287"},{"key":"ref9\/cit9c","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b02155"},{"key":"ref10\/cit10a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202303585"},{"key":"ref10\/cit10b","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b02071"},{"key":"ref10\/cit10c","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000548"},{"key":"ref10\/cit10d","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202100414"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202211892"},{"key":"ref12\/cit12a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b02026"},{"key":"ref12\/cit12b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205103"},{"key":"ref12\/cit12c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c03798"},{"key":"ref12\/cit12d","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b01947"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01788"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110213"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2019.01.057"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/ja0000495"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202106531"},{"key":"ref18\/cit18a","doi-asserted-by":"publisher","DOI":"10.1021\/ja00502a059"},{"key":"ref18\/cit18b","doi-asserted-by":"publisher","DOI":"10.1021\/jo00172a042"}],"container-title":["Organic Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.5c03367","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.5c03367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T08:18:14Z","timestamp":1757665094000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.5c03367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":51,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2025,9,12]]}},"alternative-id":["10.1021\/acs.orglett.5c03367"],"URL":"https:\/\/doi.org\/10.1021\/acs.orglett.5c03367","relation":{},"ISSN":["1523-7060","1523-7052"],"issn-type":[{"value":"1523-7060","type":"print"},{"value":"1523-7052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}