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We report the synthesis of a new chiral carboxylic acid that enables Ir(III)-catalyzed asymmetric C\u2013H activation\/desymmetrization of sulfoximines with \u03b1-bromo ketones. A diverse range of sulfur-stereogenic sulfoximines were synthesized with high yields (up to 90%) and excellent enantioselectivity (up to 97:3 er). The reaction maintained its efficiency upon scale-up, and one of the products 6aa could be readily transformed into the five-membered chiral cyclic sulfoximine derivative. Detailed mechanistic studies establish C\u2013H bond cleavage as the rate-determining step. Furthermore, the alkylated reaction intermediate was successfully isolated and demonstrated complete retention of enantioselectivity upon conversion to the corresponding product.<\/jats:p>","DOI":"10.1021\/acs.orglett.5c04553","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:01:04Z","timestamp":1769778064000},"page":"1923-1928","source":"Crossref","is-referenced-by-count":6,"title":["Chiral Carboxylic\nAcid Assisted Ir(III)-Catalyzed\nAsymmetric C\u2013H Activation\/Desymmetrization of Sulfoximines"],"prefix":"10.1021","volume":"28","author":[{"given":"Rihuang","family":"Pan","sequence":"first","affiliation":[{"name":"Zhejiang University, ZJU\u2212NHU United R&D Center , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxiao","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhejiang University, ZJU\u2212NHU United R&D Center , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang University, ZJU\u2212NHU United R&D Center , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9153-8890","authenticated-orcid":true,"given":"Yongtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang University, ZJU\u2212NHU United R&D Center , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-0507","authenticated-orcid":true,"given":"Xufeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Zhejiang University, ZJU\u2212NHU United R&D Center , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"2026073004062338800_cit1a","doi-asserted-by":"publisher","first-page":"8908","DOI":"10.1021\/acs.chemrev.6b00692","article-title":"Catalytic\nEnantioselective Transformations Involving C-H Bond Cleavage by Transition-Metal\nComplexes","volume":"117","author":"Newton","year":"2017","journal-title":"Chem. 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