{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:13:32Z","timestamp":1788279212373,"version":"build-2803163510"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100000873","name":"Queen's University Belfast","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100000873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A new synthesis of (+)-brefeldin A is reported via Padwa allenylsulfone [3 + 2]-cycloadditive elimination. Cycloadduct 13 was initially elaborated into iodide 27, which, following treatment with Zn, gave aldehyde 28 whose C(9) stereocenter was epimerized. Further elaboration into enoate 38 and Julia\u2013Kocienski olefination with 5 subsequently afforded 39, which was deprotected at C(1) and O(15). Yamaguchi macrolactonization of the seco-acid thereafter afforded a macrocycle that underwent O-desilylation and inversion at C(4) to give (+)-brefeldin A following deprotection.<\/jats:p>","DOI":"10.1021\/acs.orglett.6b02002","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T14:33:01Z","timestamp":1471617181000},"page":"4254-4257","source":"Crossref","is-referenced-by-count":16,"title":["Total Synthesis of the Antitumor Macrolides, (+)-Brefeldin\nA and 4-Epi-Brefeldin A from\n                    <scp>d<\/scp>\n                    -Glucose: Use\nof the Padwa Anionic Allenylsulfone [3 + 2]-Cycloadditive Elimination\nTo Construct Trans-Configured Chiral Cyclopentane Systems"],"prefix":"10.1021","volume":"18","author":[{"given":"Ziyue","family":"Xiong","sequence":"first","affiliation":[{"name":"The Queen\u2019s University Belfast , , Stranmillis Road , , Northern Ireland,","place":["Belfast, United Kingdom, BT9 5AG"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Hale","sequence":"additional","affiliation":[{"name":"The Queen\u2019s University Belfast , , Stranmillis Road , , Northern Ireland,","place":["Belfast, United Kingdom, BT9 5AG"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"key":"2026090111034529200_cit1a","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/1811072a0","volume":"181","author":"Singleton","year":"1958","journal-title":"Nature"},{"key":"2026090111034529200_cit1b","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1002\/hlca.19710540839","volume":"54","author":"Weber","year":"1971","journal-title":"Helv. 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