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This late-stage functionalization exhibits broad substrate scope for both phosphines and olefins. A diverse library of 55 olefin\u2013phosphines was prepared in high yields, tolerating up to 15 different functional groups. These ligands demonstrate exceptional performance in Suzuki coupling, achieving catalyst loadings as low as 0.005 mol % and surpassing commercial biarylphosphines in facilitating Pd-catalyzed C\u2013C and C\u2013X bond formations. Mechanistic studies and DFT calculations support a Ru\u2013C addition\/\u03b2-bromo elimination pathway over oxidative addition.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c01996","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:34:54Z","timestamp":1785854094000},"page":"10145-10150","source":"Crossref","is-referenced-by-count":0,"title":["Ruthenium-Catalyzed\nC\u2013H Alkenylation of Phosphines:\nReaction Development, Mechanistic Studies, and Applications to Ligand\nDesign"],"prefix":"10.1021","volume":"28","author":[{"given":"Liang-Neng","family":"Wang","sequence":"first","affiliation":[{"name":"Hubei University , , ,","place":["Wuhan, P. R. China, 430062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei University , , ,","place":["Wuhan, P. R. China, 430062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbo","family":"Cai","sequence":"additional","affiliation":[{"name":"Hubei University , , ,","place":["Wuhan, China, 430062"]},{"name":"Hubei Jiangxia Lab , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei University , , ,","place":["Wuhan, China, 430062"]},{"name":"Hubei Jiangxia Lab , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-0890","authenticated-orcid":true,"given":"Yue-Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei University , , ,","place":["Wuhan, P. R. 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