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This synthesis successfully addressed several challenges arising from a highly acid-sensitive oxazoline, a reactive nitrosohydroxyamino group, and an epimerization-prone tetramic acid. The developed synthetic route enabled access to 25-methyl\/17-methyl derivatives as potent\/stabilized FOXO3 inhibitors. This study provides a robust platform for structure\u2013activity relationship studies and future target identification in chronic myelogenous leukemia therapeutics.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02149","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:44:39Z","timestamp":1784382279000},"page":"9591-9595","source":"Crossref","is-referenced-by-count":0,"title":["Total Synthesis\nof JBIR-141 and Its Analogues: Potent\nInhibitors of Forkhead Box O3 (FOXO3)"],"prefix":"10.1021","volume":"28","author":[{"given":"Hidetoshi","family":"Ban","sequence":"first","affiliation":[{"name":"Tohoku University , , 6-3 Aza-aoba , , ,","place":["Aramaki, Sendai, Japan, 980-8578"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Yasoshima","sequence":"additional","affiliation":[{"name":"Tohoku University , , 6-3 Aza-aoba , , ,","place":["Aramaki, Sendai, Japan, 980-8578"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Ohsawa","sequence":"additional","affiliation":[{"name":"Tohoku University , , 6-3 Aza-aoba , , ,","place":["Aramaki, Sendai, Japan, 980-8578"]},{"name":"Juntendo University , , 6-8-1 Hinode , ,","place":["Urayasu, Japan, 279-0013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Suzuki","sequence":"additional","affiliation":[{"name":"University of Tsukuba , , 1-1-1 Tennodai , , ,","place":["Tsukuba, Ibaraki, Japan, 305-8571"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritaka","family":"Kagaya","sequence":"additional","affiliation":[{"name":"Technology Research Association for Next Generation Natural Products Chemistry , 2-4-7 Aomi , , ,","place":["Koto-ku, Tokyo, Japan, 135-0064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Japan Biological Informatics Consortium (JBIC) , 2-4-7 Aomi , , ,","place":["Koto-ku, Tokyo, Japan, 135-0064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-577X","authenticated-orcid":true,"given":"Hiroyuki","family":"Yamakoshi","sequence":"additional","affiliation":[{"name":"Tohoku University , , 6-3 Aza-aoba , , ,","place":["Aramaki, Sendai, Japan, 980-8578"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0252-7637","authenticated-orcid":true,"given":"Masahito","family":"Yoshida","sequence":"additional","affiliation":[{"name":"University of Tsukuba , , 1-1-1 Tennodai , , ,","place":["Tsukuba, Ibaraki, Japan, 305-8571"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4702-0661","authenticated-orcid":true,"given":"Kazuo","family":"Shin-ya","sequence":"additional","affiliation":[{"name":"National Institute of Advanced Industrial Science and Technology (AIST) , 2-4-7 Aomi , , ,","place":["Koto-ku, Tokyo, Japan, 135-0064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8306-6819","authenticated-orcid":true,"given":"Takayuki","family":"Doi","sequence":"additional","affiliation":[{"name":"Tohoku University , , 6-3 Aza-aoba , , ,","place":["Aramaki, Sendai, Japan, 980-8578"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"2026073109272231000_cit1","doi-asserted-by":"publisher","first-page":"5476","DOI":"10.1021\/acs.orglett.5b02842","article-title":"Foxo3a Inhibitors of\nMicrobial Origin, JBIR-141 and JBIR-142","volume":"17","author":"Kawahara","year":"2015","journal-title":"Org.\nLett."},{"key":"2026073109272231000_cit2a","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/s41589-018-0101-9","article-title":"Gramibactin is a bacterial siderophore\nwith a diazeniumdiolate ligand system","volume":"14","author":"Hermenau","year":"2018","journal-title":"Nat.\nChem. 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