{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:51:22Z","timestamp":1791474682888,"version":"4.3.4"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/P026990\/1"],"award-info":[{"award-number":["EP\/P026990\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000838","name":"University of Sussex","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100000838","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["HCP00037"],"award-info":[{"award-number":["HCP00037"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A late-stage, efficient C\u2013H functionalization of medicinally relevant 1,4-benzodiazepines for direct C\u2013H sulfonamidation has been developed via Ru-catalyzed C\u2013H activation. Tosyl azide (TsN3) serves as a bench-stable sulfonamidating reagent. The sulfonamidated product is further converted to an aminated product through chemoselective hydrolysis of the sulfonamide bond. In mechanistic studies, a ruthenacycle (BDZ-Ru-Cl) has been synthesized and characterized by NMR spectroscopy and SC-XRD. Additionally, a novel intermediate, Int-C (a six-membered N\u2013SO2Ar-inserted species), was synthesized from BDZ-Ru-Cl, providing further support for the proposed mechanistic pathway. Density functional theory (DFT) studies were also conducted to gain deeper mechanistic insight and to validate the developed protocol.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02186","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:29:21Z","timestamp":1784723361000},"page":"9585-9590","source":"Crossref","is-referenced-by-count":2,"title":["Ru(II)-Catalyzed\nC\u2013H Sulfonamidation of the\nMedicinally Relevant Benzodiazepine Scaffolds"],"prefix":"10.1021","volume":"28","author":[{"given":"Shourabh","family":"Rav","sequence":"first","affiliation":[{"name":"Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology , , ,","place":["Palampur, India, 176061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-9301","authenticated-orcid":true,"given":"Shiv Shankar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology , , ,","place":["Palampur, India, 176061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-7034","authenticated-orcid":true,"family":"Sarthi","sequence":"additional","affiliation":[{"name":"Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology , , ,","place":["Palampur, India, 176061"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Storm","family":"Hassell-Hart","sequence":"additional","affiliation":[{"name":"University of Sussex , , Falmer, ,","place":["Brighton, U.K., BN1 9QJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goose","family":"Markby","sequence":"additional","affiliation":[{"name":"University of Sussex , , Falmer, ,","place":["Brighton, U.K., BN1 9QJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-5417","authenticated-orcid":true,"given":"Hazel","family":"Cox","sequence":"additional","affiliation":[{"name":"University of Sussex , , Falmer, ,","place":["Brighton, U.K., BN1 9QJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5231-8836","authenticated-orcid":true,"given":"John","family":"Spencer","sequence":"additional","affiliation":[{"name":"University of Sussex , , Falmer, ,","place":["Brighton, U.K., BN1 9QJ"]},{"name":"University of Sussex , , Falmer, ,","place":["Brighton, U.K., BN1 9QJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7693-8690","authenticated-orcid":true,"given":"Upendra","family":"Sharma","sequence":"additional","affiliation":[{"name":"Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology , , ,","place":["Palampur, India, 176061"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"2026073109272527900_cit1","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1039\/C5CS00628G","article-title":"The Medicinal\nChemist\u2019s Toolbox for Late-Stage Functionalization of Drug-Like\nMolecules","volume":"45","author":"Cernak","year":"2016","journal-title":"Chem. 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