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The present study draws inspiration from the synergistic potential inherent in the merging of electrochemistry with nickel catalysis, which establishes a practical and versatile platform for asymmetric C\u2013C bond formation in synthetic chemistry. This report details an electrochemically driven, nickel-catalyzed enantioselective reductive cross-coupling of \u03b1-bromophosphonates with aryl iodides. This method delivers enantioenriched \u03b1-aryl phosphonates in excellent enantioselectivity under mild conditions, which exhibits a broad substrate scope, high functional-group tolerance, and exceptional stereocontrol, as demonstrated through the late-stage functionalization of bioactive molecules. Mechanistic studies, incorporating cyclic voltammetry and control experiments, have indicated that a NiI species activates the \u03b1-bromophosphonate via single-electron transfer.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02188","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:22:23Z","timestamp":1784636543000},"page":"9718-9723","source":"Crossref","is-referenced-by-count":0,"title":["Electrocatalytic\nEnantioselective Reductive Cross-Coupling\nfor Accessing Chiral \u03b1-Aryl Phosphonates"],"prefix":"10.1021","volume":"28","author":[{"given":"Yin-Hui","family":"Huang","sequence":"first","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8004-821X","authenticated-orcid":true,"given":"Lin","family":"Dong","sequence":"additional","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"2026073109265469800_cit1a","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1002\/anie.200803611","article-title":"Secondary Alkyl Halides in Transition-Metal-Catalyzed\nCross-Coupling Reactions","volume":"48","author":"Rudolph","year":"2009","journal-title":"Angew. 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