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Remarkable features of this reaction include mild conditions, simple operation, and a broad scope, enabling the efficient synthesis of structurally diverse trifluoromethylated 1,2,4-triazole-acyl-hydrazones in good yields. Moreover, the corresponding products could be easily transformed into bis-heterocyclic scaffolds containing triazole and oxadiazole via anion-driven C\u2013F bond activation. Experimental results and DFT calculations converge in supporting the idea that the CF3 group and temperature play a crucial role in the chemoselectivity switch.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02468","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:18:05Z","timestamp":1785849485000},"page":"9913-9918","source":"Crossref","is-referenced-by-count":0,"title":["Direct Synthesis\nof Trifluoromethylated 1,2,4-Triazole-acyl-hydrazones\nvia a One-Pot [3 + 2] Cycloaddition\/Substitution Cascade between\n                    <i>N<\/i>\n                    -Tosyl-\n                    <i>N<\/i>\n                    -aryl Cyanamides\nand Trifluoromethylated Hydrazonoyl Chlorides"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4844-8766","authenticated-orcid":true,"given":"Huamin","family":"Wang","sequence":"first","affiliation":[{"name":"University of South China , , ,","place":["Hengyang, P. R. China, 421009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiao","sequence":"additional","affiliation":[{"name":"University of South China , , ,","place":["Hengyang, P. R. China, 421009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Min","family":"Guo","sequence":"additional","affiliation":[{"name":"University of South China , , ,","place":["Hengyang, P. R. China, 421009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwan","family":"Peng","sequence":"additional","affiliation":[{"name":"University of South China , , ,","place":["Hengyang, P. R. China, 421009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ding","family":"Xie","sequence":"additional","affiliation":[{"name":"University of South China , , ,","place":["Hengyang, P. R. China, 421009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory for Environmental Catalysis & Waste Regeneration of Hunan Province, Institute of Advanced Functional Materials, College of Material and Chemical Engineering, Hunan Institute of Engineering , ,","place":["Xiangtan, P. R. China, 411228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5954-7260","authenticated-orcid":true,"given":"Junyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Jinan, P. R. China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-0871","authenticated-orcid":true,"given":"Ying-Wu","family":"Lin","sequence":"additional","affiliation":[{"name":"University of South China , , ,","place":["Hengyang, P. R. China, 421009"]},{"name":"University of South China Medical School , , ,","place":["Hengyang, P. R. China, 421009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-2846","authenticated-orcid":true,"given":"Junliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of South China , , ,","place":["Hengyang, P. R. China, 421009"]},{"name":"Fudan University , 2005 Songhu Road , ,","place":["Shanghai, P. R. China, 200437"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026080709072509400_cit1a","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1021\/np200037z","article-title":"Triazole and Dihydroimidazole\nAlkaloids from the Marine Sediment-Derived Fungus Penicillium paneum SD-44","volume":"74","author":"Li","year":"2011","journal-title":"J. Nat. 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