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This practical transformation is characterized by its high chemoselectivity and regioselectivity for ring opening of aziridines, facilitating the efficient synthesis of a wide range of valuable \u03b2-functionalized ethylamine-containing tetrasubstituted allenes in up to 95% yields. Mechanistic studies suggest that such a reductive 1,4-alkylarylation method proceeds via a radical pathway, which involves a secondary radical generated from a nonregioselective halide (bromide or iodide) ring opening of aziridines.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02492","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:16:24Z","timestamp":1785849384000},"page":"9950-9955","source":"Crossref","is-referenced-by-count":0,"title":["Nickel-Catalyzed\nReductive 1,4-Alkylarylation of 1,3-Enynes\nwith Aziridines and Aryl Electrophiles: A Route to \u03b3-Sulfonamide\nAllenes"],"prefix":"10.1021","volume":"28","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences , , , ,","place":["Jinan, Shandong, China, 250117"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Wen","family":"Shao","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences , , , ,","place":["Jinan, Shandong, China, 250117"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences , , , ,","place":["Jinan, Shandong, China, 250117"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Xie","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences , , , ,","place":["Jinan, Shandong, China, 250117"]},{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences , , , ,","place":["Jinan, Shandong, China, 250117"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-9175","authenticated-orcid":true,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences , , , ,","place":["Jinan, Shandong, China, 250117"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026080709072962400_cit1a","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nature13274","article-title":"Recent\nAdvances in Homogeneous Nickel Catalysis","volume":"509","author":"Tasker","year":"2014","journal-title":"Nature"},{"key":"2026080709072962400_cit1b","doi-asserted-by":"publisher","first-page":"8242","DOI":"10.1002\/chem.201402509","article-title":"Metal-Catalyzed Reductive\nCoupling Reactions of Organic Halides with Carbonyl-Type Compounds","volume":"20","author":"Moragas","year":"2014","journal-title":"Chem. - Eur. 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