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Despite their significance, the direct one-step synthesis of indolinimines from indoles under mild conditions remains a formidable challenge. Herein, we report a visible light-promoted radical dearomatization of indoles using readily available N-aminopyridinium salts as nitrogen-centered radical precursors. This protocol enables a mild, one-step synthesis of diverse indolinimine derivatives with good to excellent yields, featuring a broad substrate scope, excellent functional group compatibility, and operational simplicity. Mechanistic studies revealed a pathway involving amidyl radical addition to indoles, followed by dearomatization and an intramolecular cascade transformation. This work presents a green and efficient strategy for constructing a valuable indolinimine skeleton, offering potential applications in medicinal chemistry and organic synthesis.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02499","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:36:49Z","timestamp":1784306209000},"page":"9690-9695","source":"Crossref","is-referenced-by-count":1,"title":["Radical Dearomatization of Indoles with\n                    <i>N<\/i>\n                    -Aminopyridinium Salts for the Synthesis of Indolinimines"],"prefix":"10.1021","volume":"28","author":[{"given":"Zhanpan","family":"Ye","sequence":"first","affiliation":[{"name":"Fuzhou University , , ,","place":["Fuzhou, China, 350108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siping","family":"Lin","sequence":"additional","affiliation":[{"name":"Fuzhou University , , ,","place":["Fuzhou, China, 350108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fuzhou University , , ,","place":["Fuzhou, China, 350108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6330-9107","authenticated-orcid":true,"given":"Jinni","family":"Shen","sequence":"additional","affiliation":[{"name":"Fuzhou University , , ,","place":["Fuzhou, China, 350108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-262X","authenticated-orcid":true,"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Fuzhou University , , ,","place":["Fuzhou, China, 350108"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"2026073109272306100_cit1a","doi-asserted-by":"publisher","first-page":"112827","DOI":"10.1016\/j.biopha.2022.112827","article-title":"Advances in Indole-Containing Alkaloids\nas Potential Anticancer Agents by Regulating Autophagy","volume":"149","author":"Luo","year":"2022","journal-title":"Biomed. 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