{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:35:46Z","timestamp":1791974146458,"version":"4.4.0"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100020512","name":"Indian Institute of Science Education and Research Thiruvananthapuram","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100020512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","award":["MoE-STARS\/STARS-2\/2023-0147"],"award-info":[{"award-number":["MoE-STARS\/STARS-2\/2023-0147"]}],"id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a mild, redox-neutral deacylative SN2\u2032-type alkylation of monochloro- and gem-dichlorocyclobutenones with pro-aromatic ketone-derived dihydroquinazolinones enabled by visible light photocatalysis. The method uniquely combines the C\u2013C bond cleavage of unstrained aliphatic ketones with concurrent C\u2013C bond formation via \u03b1-selective radical addition to the enone moiety of gem-dichlorocyclobutenones, contrasting \u03b2-selective radical addition in Giese-type addition. This base- and oxidant-free method provides efficient access to highly functionalized 4-alkylated \u03b1-chlorocyclobutenones. Furthermore, aldehyde-derived pro-aromatic 4-alkyl-1,4-dihydropyrides served as C-radical precursors, enabling the synthesis of 4-alkylated \u03b1-chlorocyclobutenones under similar reaction conditions.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02578","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:12:48Z","timestamp":1785129168000},"page":"9962-9967","source":"Crossref","is-referenced-by-count":1,"title":["Deacylative SN2\u2032-Type Alkylation\nof Monochloro- and\n                    <i>gem<\/i>\n                    -Dichlorocyclobutenones Mediated\nby Pro-aromatic Intermediates"],"prefix":"10.1021","volume":"28","author":[{"given":"Pinku Prasad","family":"Mondal","sequence":"first","affiliation":[{"name":"Indian Institute of Science Education and Research Thiruvananthapuram , , , ,","place":["Thiruvananthapuram, Kerala, India, 695551"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Das","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Thiruvananthapuram , , , ,","place":["Thiruvananthapuram, Kerala, India, 695551"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthana","family":"Somaraj","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Thiruvananthapuram , , , ,","place":["Thiruvananthapuram, Kerala, India, 695551"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9746-9555","authenticated-orcid":true,"given":"Basudev","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Thiruvananthapuram , , , ,","place":["Thiruvananthapuram, Kerala, India, 695551"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"2026080709072305000_cit1","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1021\/acs.jcim.1c00811","article-title":"Close-up\nLook at the Chemical Space of Commercially Available Building Blocks\nfor Medicinal Chemistry","volume":"62","author":"Zabolotna","year":"2022","journal-title":"J. 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