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Herein, we describe a copper-mediated defluorinative coupling of TMSCF2CN with diazo compounds under mild conditions, providing straightforward access to highly E\/Z-selective cyanofluoroalkenes. This method features broad functional group compatibility and is amenable to the late-stage functionalization of complex molecules. Furthermore, the presence of the cyano group offers a versatile handle for further derivatization of the resulting cyanofluoroalkene products.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02581","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:02:25Z","timestamp":1785862945000},"page":"10225-10230","source":"Crossref","is-referenced-by-count":0,"title":["Copper-Mediated Selective Cyanofluoroolefination of\nDiazo Compounds with TMSCF2CN"],"prefix":"10.1021","volume":"28","author":[{"given":"Lu","family":"Yang","sequence":"first","affiliation":[{"name":"Zhengzhou University , , 97 Wenhua Road , , ,","place":["Zhengzhou, Henan, China, 450003"]},{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences , , 345 Ling-Ling Road , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaidi","family":"Zhu","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences , , 345 Ling-Ling Road , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumin","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences , , 345 Ling-Ling Road , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-7338","authenticated-orcid":true,"given":"Mingyou","family":"Hu","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences , , 345 Ling-Ling Road , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanfa","family":"Ni","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences , , 345 Ling-Ling Road , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3537-0207","authenticated-orcid":true,"given":"Jinbo","family":"Hu","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , 97 Wenhua Road , , ,","place":["Zhengzhou, Henan, China, 450003"]},{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences , , 345 Ling-Ling Road , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026081410085064000_cit1a","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1039\/B610213C","article-title":"Fluorine in\nMedicinal Chemistry","volume":"37","author":"Purser","year":"2008","journal-title":"Chem. 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Chem."},{"key":"2026081410085064000_cit2b","doi-asserted-by":"publisher","first-page":"11120","DOI":"10.1021\/jp062881n","article-title":"Fluoroolefins as peptide mimetics:\na computational study of structure, charge distribution, hydration,\nand hydrogen bonding","volume":"110","author":"Urban","year":"2006","journal-title":"J. Phys. Chem. A"},{"key":"2026081410085064000_cit3a","doi-asserted-by":"publisher","first-page":"7439","DOI":"10.1021\/ja00019a061","article-title":"Stereospecific Method to E and Z. Terminal Fluoro Olefins\nand Its Application to the Synthesis of 2\u2032-Deoxy-2\u2032-Fluoromethylene\nNucleosides as Potential Inhibitors of Ribonucleoside Diphosphate\nReductase","volume":"113","author":"McCarthy","year":"1991","journal-title":"J. Am. Chem. 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