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Furthermore, the practical utility of this method had been validated by easily scale-up synthesis, substrates derived from bioactive molecules and versatile derivatization of the target products. Mechanistic studies revealed that the reaction possibly proceeds via twice iron-mediated single-electron transfer (SET) processes. Furthermore, the resulting 3,4-disubstituted cinnolines exhibited significant anti-inflammatory effects from LPS stimulation experiment.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02586","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:22:04Z","timestamp":1785849724000},"page":"10219-10224","source":"Crossref","is-referenced-by-count":0,"title":["Fe(III)-Catalyzed\nCascade C\u2013H Functionalization\/cycloaddition\nof\n                    <i>ortho<\/i>\n                    -Alkynyl Arylhydrazides: Facial Access to\n3,4-Disubstituted Cinnolines"],"prefix":"10.1021","volume":"28","author":[{"given":"Tao","family":"Zhu","sequence":"first","affiliation":[{"name":"Gannan Medical University , , , ,","place":["Ganzhou, Jiangxi, P. R. China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lechi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , , ,","place":["Ganzhou, Jiangxi, P. R. 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