{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:27:29Z","timestamp":1786721249591,"version":"build-2736575974"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["24KJB150001"],"award-info":[{"award-number":["24KJB150001"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Vocational College of Business","award":["614009016"],"award-info":[{"award-number":["614009016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CF3-substituted oxetanes are emerging tert-butyl bioisosteres of growing interest in medicinal chemistry, yet their synthesis remains challenging. Here, we report a visible-light photocatalytic hydroalkylation of readily available \u03b1-CF3 oxetane benzoates with unactivated alkenes. Enabled by formate-mediated reductive generation of \u03b1-CF3 oxetanyl radicals, the reaction proceeds under mild conditions with broad substrate scope and functional-group tolerance, furnishing diverse CF3-substituted oxetanes from simple starting materials. This modular protocol expands access to these underexplored bioisosteric motifs and facilitates their incorporation into medicinally relevant molecules.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02598","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:05:04Z","timestamp":1785852304000},"page":"10236-10241","source":"Crossref","is-referenced-by-count":0,"title":["Photocatalytic\nDeoxygenative Hydroalkylation Enables\nModular Access to CF3-Substituted Oxetanes"],"prefix":"10.1021","volume":"28","author":[{"given":"Yi-Nan","family":"Lu","sequence":"first","affiliation":[{"name":"Jiangsu Vocational College of Business , ,","place":["Nantong, P. R. China, 226011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Vocational College of Business , ,","place":["Nantong, P. R. China, 226011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3696-8657","authenticated-orcid":true,"given":"Jia-Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Changzhou University , , , ,","place":["Changzhou, Jiangsu, P. R. China, 213164"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"2026081410091845100_cit1","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1021\/cr950066q","article-title":"Bioisosterism: A\nRational Approach in Drug Design","volume":"96","author":"Patani","year":"1996","journal-title":"Chem. Rev."},{"key":"2026081410091845100_cit2a","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1021\/jm9018788","article-title":"Oxetanes in Drug Discovery: Structural and Synthetic\nInsights","volume":"53","author":"Wuitschik","year":"2010","journal-title":"J. Med. 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Chem."},{"key":"2026081410091845100_cit3c","doi-asserted-by":"publisher","first-page":"18087","DOI":"10.1021\/acs.jafc.3c00765","article-title":"Fluorine\nand Fluorinated Motifs in the Design and Application of Bioisosteres\nfor Drug Design","volume":"71","author":"Meanwell","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"2026081410091845100_cit3d","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1021\/jm1013693","article-title":"Synopsis of Some Recent Tactical Applications of Bioisosteres\nin Drug Design","volume":"54","author":"Meanwell","year":"2011","journal-title":"J. Med. Chem."},{"key":"2026081410091845100_cit4a","doi-asserted-by":"publisher","first-page":"9769","DOI":"10.1021\/acs.jmedchem.7b01236","article-title":"Discovery of a Potent, Selective\nT-Type Calcium Channel Blocker as a Drug Candidate for the Treatment\nof Generalized Epilepsies","volume":"60","author":"Bezenc\u0327on","year":"2017","journal-title":"J. Med. Chem."},{"key":"2026081410091845100_cit4b","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1021\/acs.joc.3c00123","article-title":"General\nand Scalable Approach to Trifluoromethyl-Substituted Cyclopropanes","volume":"88","author":"Ahunovych","year":"2023","journal-title":"J. Org. Chem."},{"key":"2026081410091845100_cit4c","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/cmdc.201402502","article-title":"Evaluation of tert-Butyl Isosteres: Case Studies of\nPhysicochemical and Pharmacokinetic Properties, Efficacies, and Activities","volume":"10","author":"Westphal","year":"2015","journal-title":"ChemMedChem."},{"key":"2026081410091845100_cit4d","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1021\/acs.joc.3c00123","article-title":"General\nand Scalable Approach to Trifluoromethyl-Substituted Cyclopropanes","volume":"88","author":"Ahunovych","year":"2023","journal-title":"J. Org. 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Rev."},{"key":"2026081410091845100_cit13","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1021\/jacs.7b12590","article-title":"Catalytic Defluoroalkylation of Trifluoromethylaromatics\nwith Unactivated Alkenes","volume":"140","author":"Wang","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091845100_cit14","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1039\/C5CS00628G","article-title":"The Medicinal\nChemist\u2019s Toolbox for Late Stage Functionalization of Drug-Like\nMolecules","volume":"45","author":"Cernak","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"2026081410091845100_cit15","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1021\/j100300a045","article-title":"Reduction Potential\nof the Carbon Dioxide\/Carbon Dioxide\nRadical Anion: A Comparison with Other C1 Radicals","volume":"91","author":"Koppenol","year":"1987","journal-title":"J. Phys. Chem."}],"container-title":["Organic Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.6c02598","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/orlef7\/article-pdf\/28\/32\/10236\/66352174\/acs.orglett.6c02598.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/orlef7\/article-pdf\/28\/32\/10236\/66352174\/acs.orglett.6c02598.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:29:56Z","timestamp":1786717796000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/orlef7\/article\/28\/32\/10236\/5238171\/Photocatalytic-Deoxygenative-Hydroalkylation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":31,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,7,31]]},"published-print":{"date-parts":[[2026,8,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.orglett.6c02598","relation":{},"ISSN":["1523-7060","1523-7052"],"issn-type":[{"value":"1523-7060","type":"print"},{"value":"1523-7052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}