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The optimized reaction provides selective access to the desired products by minimizing competing reaction pathways. The method exhibits broad substrate scope for DNA-conjugated anilines and is applicable to representative DNA-conjugated aldehydes and isocyanides. This work expands the repertoire of DNA-compatible multicomponent reactions and provides access to privileged \u03b1-aminoamide scaffolds for DNA-encoded libraries.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02619","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:55:18Z","timestamp":1784642118000},"page":"9748-9754","source":"Crossref","is-referenced-by-count":1,"title":["DNA-Compatible\n\u03b1-Aminoamide Synthesis\nfor a DNA-Encoded Library"],"prefix":"10.1021","volume":"28","author":[{"given":"Juyeon","family":"Lee","sequence":"first","affiliation":[{"name":"Kyungpook National University , , ,","place":["Daegu, Republic of Korea, 41566"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub) , , ,","place":["Daegu, Republic of Korea, 41061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik Hwan","family":"Choi","sequence":"additional","affiliation":[{"name":"Kyungpook National University , , ,","place":["Daegu, Republic of Korea, 41566"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7429-9462","authenticated-orcid":true,"given":"Danila","family":"Ryzhikh","sequence":"additional","affiliation":[{"name":"Kyungpook National University , , ,","place":["Daegu, Republic of Korea, 41566"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2479-6093","authenticated-orcid":true,"given":"Ki Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Chungbuk National University , , , ,","place":["Cheongju, Chungbuk, Republic of Korea, 28644"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-4618","authenticated-orcid":true,"given":"Minsoo","family":"Song","sequence":"additional","affiliation":[{"name":"Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub) , , ,","place":["Daegu, Republic of Korea, 41061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7107-9244","authenticated-orcid":true,"given":"Gil Tae","family":"Hwang","sequence":"additional","affiliation":[{"name":"Kyungpook National University , , ,","place":["Daegu, Republic of Korea, 41566"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"2026073109265769200_cit1a","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.cbpa.2010.02.017","article-title":"Selecting Chemicals: The Emerging Utility of DNA-Encoded\nLibraries","volume":"14","author":"Clark","year":"2010","journal-title":"Curr. 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