{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:30Z","timestamp":1791331230045,"version":"4.3.1"},"reference-count":28,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Science and Technology Serving Projects of Yunnan Universities Key Industries","award":["FWCY-BSPY2025074"],"award-info":[{"award-number":["FWCY-BSPY2025074"]}]},{"name":"Yunnan University Interdisciplinary Team Project","award":["CZ22621802"],"award-info":[{"award-number":["CZ22621802"]}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"crossref","award":["202601AY070001-242"],"award-info":[{"award-number":["202601AY070001-242"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Three rearranged jatrophane diterpenoids, eupheilosnoids A\u2013C (1\u20133), were isolated from Euphorbia helioscopia. Compound 1 possesses a fused 5\/6\/6\/4 tetracyclic carbon skeleton, whereas compounds 2 and 3 feature a 5\/6\/6\/5 ring system. Compounds 1\u20133 were evaluated for anti-ZIKV activity. Among them, compound 2 exhibited potent anti-ZIKV activity with an EC50 of 2.09 \u03bcM, which was significantly superior to that of the positive control ribavirin (RBV). Further studies revealed that compound 2 significantly inhibited the expression of ZIKV envelope protein (ZIKV-E).<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02633","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:04:07Z","timestamp":1785852247000},"page":"10253-10258","source":"Crossref","is-referenced-by-count":1,"title":["Rearranged Jatrophane\nDiterpenoids from\n                    <i>Euphorbia helioscopia<\/i>\n                    with 5\/6\/6\/4 and 5\/6\/6\/5 Fused\nSkeletons and Potent Anti-ZIKV Activity"],"prefix":"10.1021","volume":"28","author":[{"given":"Xiong","family":"Qiu","sequence":"first","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, People\u2019s Republic of China, 650500"]},{"name":"Southwest United Graduate School , , ,","place":["Kunming, People\u2019s Republic of China, 650092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan-Pan","family":"Pang","sequence":"additional","affiliation":[{"name":"Kunming Medical University , , ,","place":["Kunming, Yunan, People\u2019s Republic of China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Yue","sequence":"additional","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, People\u2019s Republic of China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Zhong","family":"Luo","sequence":"additional","affiliation":[{"name":"Kunming Medical University , , ,","place":["Kunming, Yunan, People\u2019s Republic of China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, People\u2019s Republic of China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-1993","authenticated-orcid":true,"given":"Wei-Lie","family":"Xiao","sequence":"additional","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, People\u2019s Republic of China, 650500"]},{"name":"Southwest United Graduate School , , ,","place":["Kunming, People\u2019s Republic of China, 650092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6981-0210","authenticated-orcid":true,"given":"Chang-Bo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Kunming Medical University , , ,","place":["Kunming, Yunan, People\u2019s Republic of China, 650500"]},{"name":"Kunming Medical University , , ,","place":["Kunming, Yunan, People\u2019s Republic of China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9640-7398","authenticated-orcid":true,"given":"Xiao-Li","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan University , , ,","place":["Kunming, People\u2019s Republic of China, 650500"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"2026081410095617400_cit1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00383-26","article-title":"Research progress on the association\nbetween viruses and cardiac diseases","volume":"100","author":"Yu","year":"2026","journal-title":"J. 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Sci."},{"key":"2026081410095617400_cit5","doi-asserted-by":"publisher","first-page":"105614","DOI":"10.1016\/j.fitote.2023.105614","article-title":"Euphopias G - J,\nmacrocyclic diterpenes with anti-zika virus activity from Euphorbia helioscopia L","volume":"169","author":"Qiu","year":"2023","journal-title":"Fitoterapia"},{"key":"2026081410095617400_cit6","doi-asserted-by":"publisher","first-page":"8579","DOI":"10.1021\/cr400541j","article-title":"Euphorbia diterpenes:\nisolation, structure, biological\nactivity, and synthesis (2008\u20132012)","volume":"114","author":"Vasas","year":"2014","journal-title":"Chem. 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Prod."},{"key":"2026081410095617400_cit20","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1021\/acs.orglett.1c04145","article-title":"Diterpenoids with\nrearranged 9(10\u219211)-abeo-10,12-cyclojatrophane\nskeleton and the first (15S)-jatrophane from Euphorbia helioscopia: Structural elucidation, biomimetic conversion, and their immunosuppressive\neffects","volume":"24","author":"Xiang","year":"2022","journal-title":"Org. Lett."},{"key":"2026081410095617400_cit21","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1021\/cr200106v","article-title":"Computational\nprediction of 1H and 13C chemical shifts: a\nuseful tool for natural\nproduct, mechanistic, and synthetic organic chemistry","volume":"112","author":"Lodewyk","year":"2012","journal-title":"Chem. 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Soc."},{"key":"2026081410095617400_cit28","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.17199","article-title":"An independent\nbiosynthetic route\nto frame a xanthanolide-type sesquiterpene lactone in Asteraceae","volume":"121","author":"Li","year":"2025","journal-title":"Plant J."}],"container-title":["Organic Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.6c02633","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/orlef7\/article-pdf\/28\/32\/10253\/66350163\/acs.orglett.6c02633.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/orlef7\/article-pdf\/28\/32\/10253\/66350163\/acs.orglett.6c02633.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:16:39Z","timestamp":1786716999000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/orlef7\/article\/28\/32\/10253\/5238057\/Rearranged-Jatrophane-Diterpenoids-from-Euphorbia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":28,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,7,31]]},"published-print":{"date-parts":[[2026,8,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.orglett.6c02633","relation":{},"ISSN":["1523-7060","1523-7052"],"issn-type":[{"value":"1523-7060","type":"print"},{"value":"1523-7052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}