{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:02:04Z","timestamp":1786719724822,"version":"build-2736575974"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["24ZR1465500"],"award-info":[{"award-number":["24ZR1465500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China National Pharmaceutical Industry Research Institute Co., Ltd","award":["2022TS005"],"award-info":[{"award-number":["2022TS005"]}]},{"name":"China National Pharmaceutical Industry Research Institute Co., Ltd","award":["NKLYT2026019"],"award-info":[{"award-number":["NKLYT2026019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report the collective total syntheses of four 17(15\u219216),18(4\u21923)-diabeo-abietane diterpenoids via a concise and enantioselective route (11\u201313 steps). Central to this strategy is a bioinspired polyene cyclization\/Wagner\u2013Meerwein rearrangement cascade, which directly forges the challenging tricyclic framework with high enantioselectivity. A subsequent Pd-catalyzed intramolecular cross-electrophile coupling efficiently assembles the key 6\/6\/6\/5 tetracyclic core. This core serves as a versatile platform for accessing these diterpenes and can be elaborated into caryopterisoid C (6), a compound with anti-AKI activity. Furthermore, we demonstrate for the first time that ceric ammonium nitrate can mediate an epoxidation reaction.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02634","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:20:03Z","timestamp":1785849603000},"page":"10248-10252","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetric Synthesis\nof Uncinatone, Bracteatum A,\nTrichotomone F, and Caryopterisoid C"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6883-5042","authenticated-orcid":true,"given":"Xudong","family":"Mao","sequence":"first","affiliation":[{"name":"Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyue","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"2026081410082653000_cit1a","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1039\/C4NP00110A","article-title":"Aromatic Abietane Diterpenoids: Their Biological Activity\nand Synthesis","volume":"32","author":"Gonzalez","year":"2015","journal-title":"Nat. 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Biodivers."},{"key":"2026081410082653000_cit4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.25135\/rnp.245.21.03.2000","article-title":"Diterpenoids from the Roots of Clerodendrum bungei","volume":"16","author":"Wu","year":"2021","journal-title":"Rec. Nat. Prod."},{"key":"2026081410082653000_cit5","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/hlca.19850680612","article-title":"Uncinatone,\na New Antifungal Hydroquinone Diterpenoid from Clerodendrum uncinatum Schinz","volume":"68","author":"Dorsaz","year":"1985","journal-title":"Helv. Chim. 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Soc."},{"key":"2026081410082653000_cit23c","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nature12284","article-title":"Metal-Free Oxidation of Aromatic\nCarbon-Hydrogen Bonds through a Reverse-Rebound Mechanism","volume":"499","author":"Yuan","year":"2013","journal-title":"Nature"},{"key":"2026081410082653000_cit24","doi-asserted-by":"publisher","first-page":"18731","DOI":"10.1021\/jacs.3c06031","article-title":"Concise Total Syntheses of the 6\u20137\u20135\nHamigeran Natural Products","volume":"145","author":"Jiang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410082653000_cit25","doi-asserted-by":"publisher","first-page":"13397","DOI":"10.1021\/acs.chemrev.4c00524","article-title":"Cross-Electrophile\nCoupling: Principles, Methods, and Applications in Synthesis","volume":"124","author":"Ehehalt","year":"2024","journal-title":"Chem. 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Am. 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