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This three-component radical coupling constructs two new C\u2013C bonds in a single operation, affording a range of quaternary \u03b3-amino ketones in moderate to excellent yields with broad substrate scope and good functional group tolerance. The reaction operates under mild, room-temperature conditions and uses renewable proline feedstocks. Gram-scale synthesis further demonstrates the scalability and practicality of this green protocol.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02674","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:00:16Z","timestamp":1785128416000},"page":"10063-10068","source":"Crossref","is-referenced-by-count":0,"title":["Dual Photoredox\/NHC Catalysis with a Renewable Feedstock:\nAccessing Quaternary \u03b3-Amino Ketones from Proline"],"prefix":"10.1021","volume":"28","author":[{"given":"Xuewei","family":"Hou","sequence":"first","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, People\u2019s Republic of China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Ma","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, People\u2019s Republic of China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, People\u2019s Republic of China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-477X","authenticated-orcid":true,"given":"Yuxiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, People\u2019s Republic of China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7105-1196","authenticated-orcid":true,"given":"Hongjian","family":"Song","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, People\u2019s Republic of China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7329-8389","authenticated-orcid":true,"given":"Xiaochen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Medical University , , ,","place":["Taiyuan, China, 030001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-3766","authenticated-orcid":true,"given":"Qingmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, People\u2019s Republic of China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"2026080709065293200_cit1","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1016\/j.bmc.2007.11.030","article-title":"Design and synthesis of a siderophore\nconjugate as a potent PSMA inhibitor and potential diagnostic agent\nfor prostate cancer","volume":"16","author":"Ding","year":"2008","journal-title":"Bioorg. 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