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This tandem reaction forms two carbon\u2013oxygen bonds and two carbon\u2013carbon bonds in a single operation. The mechanism of this reaction involves sequential intramolecular Heck cyclization, alkyne coordination, and nucleophilic attack by oxygen. Mechanistic studies indicate that water or the base serves as oxygen source and that the aryl iodide substrate plays a dual role as both a coupling partner and an oxidant.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02695","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:23:39Z","timestamp":1784183019000},"page":"9787-9793","source":"Crossref","is-referenced-by-count":0,"title":["Access to Functionalized\nIsocoumarin Via Palladium-Catalyzed\nTandem Heck Cyclization\/Lactonization"],"prefix":"10.1021","volume":"28","author":[{"given":"Hongbo","family":"Qi","sequence":"first","affiliation":[{"name":"Inner Mongolia University , , ,","place":["Hohhot, China, 010021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[{"name":"Inner Mongolia University , , ,","place":["Hohhot, China, 010021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Cong","family":"Li","sequence":"additional","affiliation":[{"name":"Inner Mongolia University , , ,","place":["Hohhot, China, 010021"]},{"name":"Inner Mongolia Academy of Science and Technology , ,","place":["Hohhot, China, 010051"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leming","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia University , , ,","place":["Hohhot, China, 010021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7021-2581","authenticated-orcid":true,"given":"Shufeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Inner Mongolia University , , ,","place":["Hohhot, China, 010021"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026073109275132900_cit1a","doi-asserted-by":"publisher","first-page":"8049","DOI":"10.1039\/D2RA08245D","article-title":"Recent advances\nin the discovery, biosynthesis, and therapeutic potential of isocoumarins\nderived from fungi: a comprehensive update","volume":"13","author":"Tammam","year":"2023","journal-title":"RSC Adv."},{"key":"2026073109275132900_cit1b","doi-asserted-by":"publisher","first-page":"112","DOI":"10.2174\/1570179415666180924123439","article-title":"3,4-Dihydroisocoumarins,\nInteresting Natural Products: Isolation, Organic Syntheses and Biological\nActivities","volume":"16","author":"Ortiz","year":"2019","journal-title":"Curr. 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