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Using chiral ruthenium catalysts modified by (S)-Cy-SEGPHOS or (R)-Cy-BINAP, high levels of enantioselectivity are obtained in reactions of azines. Late-stage C\u2013H functionalization of the B(Epin) derivative of bortezomib (Velcade) and studies corroborating the reaction mechanism are described.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02697","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:21:01Z","timestamp":1784812861000},"page":"10015-10021","source":"Crossref","is-referenced-by-count":1,"title":["Ruthenium-Catalyzed\nConjugation of Phenyl and Pyridyl\nBioisosteres to Azines\/Azoles via Dearomative Addition\u2013Hydrogen\nAuto-Transfer"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6687-2466","authenticated-orcid":true,"given":"Yhin Sarah","family":"Teoh","sequence":"first","affiliation":[{"name":"University of Texas at Austin , , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2279-3353","authenticated-orcid":true,"given":"Peyton W.","family":"Meares","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3946-7924","authenticated-orcid":true,"given":"Erin M.","family":"McManus","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5088-4858","authenticated-orcid":true,"given":"King-Long","family":"Or","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Gevirtzman","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1821-9011","authenticated-orcid":true,"given":"Pavel K.","family":"Mykhailiuk","sequence":"additional","affiliation":[{"name":"Enamine Ltd. , Winston Churchill St. 78 , ,","place":["Kyiv, Ukraine, 02094"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-9709","authenticated-orcid":true,"given":"Michael J.","family":"Krische","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026080709071308300_cit1a","doi-asserted-by":"publisher","first-page":"10257","DOI":"10.1021\/jm501100b","article-title":"Analysis of the Structural Diversity,\nSubstitution Patterns, and Frequency of Nitrogen Heterocycles among\nU.S. FDA Approved Pharmaceuticals","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. 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