{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:28:34Z","timestamp":1786721314828,"version":"build-2736575974"},"reference-count":86,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ60013"],"award-info":[{"award-number":["2026JJ60013"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M780931"],"award-info":[{"award-number":["2025M780931"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2026RC1026"],"award-info":[{"award-number":["2026RC1026"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22471068"],"award-info":[{"award-number":["22471068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["225B2105"],"award-info":[{"award-number":["225B2105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While formal cross-dimerization of strained rings and (3+X) cycloadditions of bicyclobutanes (BCBs) have enabled diverse cyclic frameworks and bicyclo[n.1.1]alkanes, respectively, their extension to bridged tricycles remains elusive. Herein, we report a Lewis acid-catalyzed formal (6 + 3) cycloaddition of BCBs with dithioazabicycles, enabling efficient access to structurally complex 9-membered thia-aza-bridged tricycles under mild conditions (up to 99% yield). This transformation proceeds via a highly selective C\u2013C\/C\u2013S bond cross-exchange process and features broad substrate scope, gram-scale synthesis, and versatile downstream derivatization.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02727","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:04:09Z","timestamp":1785852249000},"page":"10283-10289","source":"Crossref","is-referenced-by-count":0,"title":["Construction\nof Bridged Tricycles by Lewis Acid-Catalyzed\nFormal Cross-Dimerization of Bicyclobutanes with Dithioazabicycles"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8947-192X","authenticated-orcid":true,"given":"Chang-Hai","family":"Yu","sequence":"first","affiliation":[{"name":"Hunan University , , , ,","place":["Changsha, Hunan, P. R. China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5155-9099","authenticated-orcid":true,"given":"Yuanjiu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Hunan University , , , ,","place":["Changsha, Hunan, P. R. China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Hunan University , , , ,","place":["Changsha, Hunan, P. R. China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4575-148X","authenticated-orcid":true,"given":"Heng-Xian","family":"He","sequence":"additional","affiliation":[{"name":"Hunan University , , , ,","place":["Changsha, Hunan, P. R. China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-3268","authenticated-orcid":true,"given":"Jian-Jun","family":"Feng","sequence":"additional","affiliation":[{"name":"Hunan University , , , ,","place":["Changsha, Hunan, P. R. China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"2026081410091425200_cit1a","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s41061-025-00502-2","article-title":"Applications of Bridgehead\nHeterocycles in Drug Design and Medicinal Chemistry","volume":"383","author":"Di Martino","year":"2025","journal-title":"Top. Curr. Chem."},{"key":"2026081410091425200_cit1b","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1039\/c1cs15018a","article-title":"Domino Reactions for the Synthesis\nof Bridged Bicyclic Frameworks: Fast Access to Bicyclo[n.3.1]Alkanes","volume":"40","author":"Ruiz","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"2026081410091425200_cit1c","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1021\/acs.accounts.0c00798","article-title":"Tetracyclic Diterpenoid Synthesis Facilitated by ODI-Cascade\nApproaches to Bicyclo[3.2.1]octane Skeletons","volume":"54","author":"Gao","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"2026081410091425200_cit1d","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1039\/D5CS01128K","article-title":"Synthesis of heterobicyclo[n.1.1]alkanes","volume":"55","author":"Revie","year":"2026","journal-title":"Chem. Soc. Rev."},{"key":"2026081410091425200_cit1e","doi-asserted-by":"publisher","first-page":"112859","DOI":"10.1016\/j.cclet.2026.112859","article-title":"Enantioselective Palladium-Catalyzed\nTsuji\u2013Trost-Type Domino Annulation for Access to [3.3.1] Bridged\nBicycles","volume":"37","author":"Li","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"2026081410091425200_cit1f","doi-asserted-by":"publisher","first-page":"13845","DOI":"10.1021\/jacs.5c21425","article-title":"One-Step-Three-Ring Propellanation\nReaction of Yne-Vinylcyclobutanones Catalyzed by Nickel: Reaction\nDevelopment, Mechanism, and Formal Synthesis of Modhephene","volume":"148","author":"Ma","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091425200_cit1g","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41557-025-01746-7","article-title":"Enantioselective\nphotocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity","volume":"17","author":"Garrido-Garci\u0301a","year":"2025","journal-title":"Nat. Chem."},{"key":"2026081410091425200_cit1h","first-page":"1","article-title":"Research Progress in Total Synthesis of Daphenylline","volume":"47","author":"Liu","year":"2025","journal-title":"Chem. Reagents."},{"key":"2026081410091425200_cit2a","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/s41570-024-00623-0","article-title":"Three-Dimensional\nSaturated C(sp3)-Rich Bioisosteres for Benzene","volume":"8","author":"Tsien","year":"2024","journal-title":"Nat. Rev. Chem."},{"key":"2026081410091425200_cit2b","doi-asserted-by":"publisher","first-page":"14046","DOI":"10.1021\/acs.jmedchem.1c01215","article-title":"Bioisosteres of the Phenyl Ring: Recent Strategic Applications\nin Lead Optimization and Drug Design","volume":"64","author":"Subbaiah","year":"2021","journal-title":"J. Med.\nChem."},{"key":"2026081410091425200_cit2c","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1039\/C8OB02812E","article-title":"Saturated Bioisosteres\nof Benzene: Where to Go Next?","volume":"17","author":"Mykhailiuk","year":"2019","journal-title":"Org. Biomol.\nChem."},{"key":"2026081410091425200_cit3a","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s42004-022-00811-3","article-title":"Bicyclobutanes\nas Unusual Building Blocks for Complexity\nGeneration in Organic Synthesis","volume":"6","author":"Golfmann","year":"2023","journal-title":"Commun. Chem."},{"key":"2026081410091425200_cit3b","doi-asserted-by":"publisher","first-page":"100070","DOI":"10.1016\/j.tchem.2024.100070","article-title":"Strain-Release Transformations of Bicyclo[1.1.0]Butanes and [1.1.1]Propellanes","volume":"9","author":"Hu","year":"2024","journal-title":"Tetrahedron Chem."},{"key":"2026081410091425200_cit3c","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505803","article-title":"Catalytic Asymmetric Synthesis of\nChiral Caged Hydrocarbons as Arenes Bioisosteres","volume":"64","author":"Yang","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit3d","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.31635\/ccschem.025.202505825","article-title":"Catalytic Asymmetric Strategies for\nBicyclo[1.1.0]Butane Transformations: Advances and Applications","volume":"7","author":"Xiao","year":"2025","journal-title":"CCS Chem."},{"key":"2026081410091425200_cit3e","doi-asserted-by":"publisher","first-page":"5776","DOI":"10.1039\/D5CS01224D","article-title":"Catalytic Strain-Release\nEnabled Cycloaddition of Carbonyl Activated Bicyclo[1.1.0]Butanes","volume":"55","author":"Wang","year":"2026","journal-title":"Chem. Soc. Rev."},{"key":"2026081410091425200_cit3f","doi-asserted-by":"publisher","first-page":"5572","DOI":"10.1039\/D6CS00010J","article-title":"Recent Advances in the Strain-Release\nDriven Reactions of Bicyclobutanes: An Emerging Landscape in Organic\nSynthesis","volume":"55","author":"Deswal","year":"2026","journal-title":"Chem. Soc. Rev."},{"key":"2026081410091425200_cit3g","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1007\/s11426-025-2941-2","article-title":"Controllable Divergent Transformations\nof Bicyclo[1.1.0]Butanes","volume":"69","author":"He","year":"2026","journal-title":"Sci. China Chem."},{"key":"2026081410091425200_cit3h","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41586-022-04636-x","article-title":"Intermolecular\n[2\u03c0+2\u03c3]-Photocycloaddition Enabled by Triplet Energy Transfer","volume":"605","author":"Kleinmans","year":"2022","journal-title":"Nature"},{"key":"2026081410091425200_cit3i","doi-asserted-by":"publisher","first-page":"7988","DOI":"10.1021\/jacs.2c02976","article-title":"Strain-Release [2\u03c0 + 2\u03c3]\nCycloadditions for the Synthesis of Bicyclo[2.1.1]Hexanes Initiated\nby Energy Transfer","volume":"144","author":"Guo","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091425200_cit3j","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204719","article-title":"Beyond Bioisosteres: Divergent Synthesis\nof Azabicyclohexanes and Cyclobutenyl Amines from Bicyclobutanes","volume":"61","author":"Dhake","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit3k","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41557-024-01710-x","article-title":"Enantioselective Synthesis of 2-Substituted Bicyclo[1.1.1]Pentanes\nvia Sequential Asymmetric Imine Addition of Bicyclo[1.1.0]Butanes\nand Skeletal Editing","volume":"17","author":"Che","year":"2025","journal-title":"Nat. Chem."},{"key":"2026081410091425200_cit3l","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202406548","article-title":"Zinc-Catalyzed\nEnantioselective Formal (3 + 2) Cycloadditions of Bicyclobutanes with\nImines: Catalytic Asymmetric Synthesis of Azabicyclo[2.1.1]Hexanes","volume":"63","author":"Wu","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit3m","doi-asserted-by":"publisher","first-page":"111963","DOI":"10.1016\/j.cclet.2025.111963","article-title":"Lewis Acid\nCatalyzed Enantioselective Dearomative (3 + 2) Cycloaddition of Aromatic\nN-Heterocycles with Bicyclobutanes","volume":"37","author":"Wu","year":"2026","journal-title":"Chin. Chem.\nLett."},{"key":"2026081410091425200_cit3n","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308606","article-title":"Intermolecular Formal Cycloaddition of Indoles with\nBicyclo[1.1.0]Butanes by Lewis Acid Catalysis","volume":"62","author":"Ni","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit3o","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/cjoc.70355","article-title":"Chemo-,\nDiastereo-, and Enantioselective (3 + 2) Cycloadditons of Bicyclobutanes\nwith Enals Enabled by Synergistic Palladium and Organocatalysis","volume":"44","author":"Wu","year":"2026","journal-title":"Chin. J. Chem."},{"key":"2026081410091425200_cit3p","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s11426-025-2698-2","article-title":"Silver-Catalyzed Formal [2\u03c0+2\u03c3]\nCycloaddition of Bicyclobutanes with Naphthols as Surrogates for Arynes","volume":"69","author":"Tang","year":"2026","journal-title":"Sci. China Chem."},{"key":"2026081410091425200_cit3q","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.1021\/acs.orglett.4c01219","article-title":"B(C6 F5)3 -Catalyzed Formal (n + 3) (n = 5 and 6) Cycloaddition of Bicyclo[1.1.0]Butanes\nto Medium Bicyclo[n.1.1]Alkanes","volume":"26","author":"Yang","year":"2024","journal-title":"Org. Lett."},{"key":"2026081410091425200_cit3r","doi-asserted-by":"publisher","first-page":"27830","DOI":"10.1021\/jacs.4c10153","article-title":"Divergent Enantioselective Access to Diverse Chiral\nCompounds from Bicyclo[1.1.0]Butanes and \u03b1,\u03b2-Unsaturated\nKetones under Catalyst Control","volume":"146","author":"Jeong","year":"2024","journal-title":"J. Am. Chem.\nSoc."},{"key":"2026081410091425200_cit3s","doi-asserted-by":"publisher","first-page":"111072","DOI":"10.1016\/j.cclet.2025.111072","article-title":"Palladium-Catalyzed\nEnantioselective [2\u03c3 + 2\u03c0] Cycloadditions of Vinyl-Carbonyl-Bicyclo[1.1.0]Butanes\nwith Arylidenemalononitriles","volume":"37","author":"Qin","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"2026081410091425200_cit3t","doi-asserted-by":"publisher","first-page":"110540","DOI":"10.1016\/j.cclet.2024.110540","article-title":"Catalyst-Free, Visible-Light-Induced\n[2\u03c0 + 2\u03c3] Cycloaddition towards Azabicyclohexanes","volume":"36","author":"Yan","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"2026081410091425200_cit3u","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318476","article-title":"Eu(OTf)3 -Catalyzed Formal Dipolar [4\u03c0+2\u03c3] Cycloaddition of Bicyclo-[1.1.0]Butanes\nwith Nitrones: Access to Polysubstituted 2-Oxa-3-azabicyclo[3.1.1]Heptanes","volume":"63","author":"Zhang","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit3v","doi-asserted-by":"publisher","first-page":"367","DOI":"10.6023\/cjoc202500001","article-title":"Lewis Acid Catalyzed (3 + 3) Cyclization Reaction of Bicyclobutanes\nPromoted by Cross-Exchange-Based Ring Expansion","volume":"45","author":"Zhang","year":"2025","journal-title":"Chin. J. Org. Chem."},{"key":"2026081410091425200_cit4a","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1021\/acs.accounts.9b00640","article-title":"Total Synthesis\nof Natural Products with Bridged Bicyclo[m.n.1] Ring Systems via Type\nII [5 + 2] Cycloaddition","volume":"53","author":"Min","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"2026081410091425200_cit4b","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1021\/cr9002402","article-title":"Novel Syntheses of Bridge-Containing Organic Compounds","volume":"110","author":"Zhao","year":"2010","journal-title":"Chem. Rev."},{"key":"2026081410091425200_cit4c","doi-asserted-by":"publisher","first-page":"11373","DOI":"10.1038\/s41467-025-66363-x","article-title":"Catalytic Asymmetric Tandem Heck\/Sonogashira Reaction\nEnabling Access to Versatile Chiral Bridged Ring Scaffolds","volume":"16","author":"Zhong","year":"2025","journal-title":"Nat. Commun."},{"key":"2026081410091425200_cit4d","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1002\/cjoc.202400085","article-title":"Synthetic Studies toward Pseudolaric\nAcids: Radical Cyclization to Form Bridged Scaffold","volume":"42","author":"Niu","year":"2024","journal-title":"Chin. J. Chem."},{"key":"2026081410091425200_cit4e","doi-asserted-by":"publisher","first-page":"111202","DOI":"10.1016\/j.cclet.2025.111202","article-title":"Diverse Synthesis\nof Bridged Bicyclo[3.2.1]Octa-2,6-Diene and Tricyclo[3.2.1.02,7]Oct-3-Ene Frameworks via Stepwise Cascade Reactions","volume":"36","author":"Zheng","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"2026081410091425200_cit5a","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1055\/s-0037-1610266","article-title":"Recent Progress in\n\u03c3-Bond Cross-Exchange Reactions to Access Diverse Silacycles","volume":"29","author":"Zhao","year":"2018","journal-title":"Synlett"},{"key":"2026081410091425200_cit5b","doi-asserted-by":"publisher","first-page":"5359","DOI":"10.1039\/D1CC00998B","article-title":"Relieving the Stress Together: Annulation of Two Different\nStrained Rings towards the Formation of Biologically Significant Heterocyclic\nScaffolds","volume":"57","author":"Ghosh","year":"2021","journal-title":"Chem. Commun."},{"key":"2026081410091425200_cit5c","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.1039\/D2QO00410K","article-title":"Recent Advances in the Reactions of Silacyclobutanes and Their Applications","volume":"9","author":"Huang","year":"2022","journal-title":"Org. Chem. Front."},{"key":"2026081410091425200_cit6","doi-asserted-by":"publisher","first-page":"6028","DOI":"10.1016\/j.tetlet.2010.09.031","article-title":"Ring Expansion Reactions\nof Ethyl Cyclopropylideneacetate and Benzosilacyclobutenes: Formal\n\u03c3 Bond Cross Metathesis","volume":"51","author":"Saito","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"2026081410091425200_cit7a","doi-asserted-by":"publisher","first-page":"5912","DOI":"10.1021\/ja502601g","article-title":"Cleavage of\nC\u2013C\nand C\u2013Si \u03c3-Bonds and Their Intramolecular Exchange","volume":"136","author":"Ishida","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091425200_cit7b","doi-asserted-by":"publisher","first-page":"12414","DOI":"10.1021\/jacs.7b07667","article-title":"Palladium-Catalyzed Intermolecular\nExchange between C\u2013C and C\u2013Si \u03c3-Bonds","volume":"139","author":"Okumura","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091425200_cit8","doi-asserted-by":"publisher","first-page":"10338","DOI":"10.1002\/anie.201805258","article-title":"(3 + 3)-Annulation\nof Donor\u2013Acceptor Cyclopropanes with Diaziridines","volume":"57","author":"Chagarovskiy","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit9a","doi-asserted-by":"publisher","first-page":"6329","DOI":"10.1002\/anie.201803156","article-title":"Intermolecular \u03c3-Bond\nCross-Exchange Reaction between Cyclopropenones and (Benzo)silacyclobutanes:\nStraightforward Access towards Sila(benzo)cycloheptenones","volume":"57","author":"Zhao","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit9b","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/s41557-021-00746-7","article-title":"A Ring Expansion Strategy towards Diverse Azaheterocycles","volume":"13","author":"Li","year":"2021","journal-title":"Nat. Chem."},{"key":"2026081410091425200_cit9c","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.31635\/ccschem.023.202302938","article-title":"Reversing\nSite-Selectivity in Formal Cross-Dimerization of Benzocyclobutenones\nand Silacyclobutanes","volume":"5","author":"Zhang","year":"2023","journal-title":"CCS Chem."},{"key":"2026081410091425200_cit9d","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319187","article-title":"Ring Expansion toward Disila-carbocycles via Highly Selective C-Si\/C-Si\nBond Cross-Exchange","volume":"63","author":"Liu","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit10a","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1021\/om0607245","article-title":"Synthesis\nof 4:5-Benzo-1-cobalta-2-silacyclopentenes and Their Reactions with\nAlkynes and Alkenes: An Expedient Route to Silicon-Containing Polycyclic\nFrameworks","volume":"26","author":"Agenet","year":"2007","journal-title":"Organometallics"},{"key":"2026081410091425200_cit10b","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jorganchem.2015.07.040","article-title":"Studies on the Pd-Catalyzed Dimerization\nof Silacyclobutanes","volume":"797","author":"Aborways","year":"2015","journal-title":"J. Organomet. Chem."},{"key":"2026081410091425200_cit10c","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/anie.201913060","article-title":"Controllable Si-C Bond Activation Enables Stereocontrol in the Palladium-Catalyzed\n[4 + 2] Annulation of Cyclopropenes with Benzosilacyclobutanes","volume":"59","author":"Wang","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit11a","doi-asserted-by":"publisher","first-page":"12502","DOI":"10.1002\/anie.201906754","article-title":"Catalytic Desymmetric\nCycloaddition of Diaziridines with Metalloenolcarbenes: The Role of\nDonor\u2013Acceptor Cyclopropenes","volume":"58","author":"Zheng","year":"2019","journal-title":"Angew.\nChem., Int. Ed."},{"key":"2026081410091425200_cit11b","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1039\/C9CC10089J","article-title":"Expedient\nIron-Catalyzed Stereospecific Synthesis of Triazines via Cycloaddition of Aziridines with Diaziridines","volume":"56","author":"Sarkar","year":"2020","journal-title":"Chem. Commun."},{"key":"2026081410091425200_cit12","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1039\/CC9960001865","article-title":"Unexpected Cross-Metathesis between\nSi\u2013C and Si\u2013Si Bonds","volume":"16","author":"Reddy","year":"1996","journal-title":"Chem. Commun."},{"key":"2026081410091425200_cit13a","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1021\/cr010016n","article-title":"Donor\u2013Acceptor-Substituted\nCyclopropane Derivatives and Their Application in Organic Synthesis","volume":"103","author":"Reissig","year":"2003","journal-title":"Chem. Rev."},{"key":"2026081410091425200_cit13b","doi-asserted-by":"publisher","first-page":"5504","DOI":"10.1002\/anie.201309886","article-title":"A New Golden Age for Donor\u2013Acceptor\nCyclopropanes","volume":"53","author":"Schneider","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit13c","first-page":"847","article-title":"Progress\nin Cycloaddition Reactions of Cyclopropane","volume":"40","author":"Gao","year":"2018","journal-title":"Chem. Reagents"},{"key":"2026081410091425200_cit13d","doi-asserted-by":"publisher","first-page":"9226","DOI":"10.1002\/anie.201704619","article-title":"Ring-Opening 1-Amino-3-aminomethylation\nof Donor\u2013Acceptor Cyclopropanes via 1,3-Diazepanes","volume":"56","author":"Garve","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit13e","doi-asserted-by":"publisher","first-page":"5752","DOI":"10.1021\/acscatal.3c01219","article-title":"Asymmetric\n(5 + 3) Annulation of Donor\u2013Acceptor Cyclopropanes with Imidazolidines:\nAccess to Saturated 1,4-Diazocanes","volume":"13","author":"Yang","year":"2023","journal-title":"ACS Catal."},{"key":"2026081410091425200_cit14","doi-asserted-by":"publisher","first-page":"23685","DOI":"10.1021\/jacs.2c11501","article-title":"Photochemical\nIntermolecular [3\u03c3+2\u03c3]-Cycloaddition\nfor the Construction of Aminobicyclo[3.1.1]Heptanes","volume":"144","author":"Zheng","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091425200_cit15","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1021\/jacs.2c13740","article-title":"Selective [2\u03c3+2\u03c3] Cycloaddition\nEnabled by Boronyl Radical Catalysis: Synthesis of Highly Substituted\nBicyclo[3.1.1]Heptanes","volume":"145","author":"Yu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091425200_cit16","doi-asserted-by":"publisher","first-page":"25411","DOI":"10.1021\/jacs.3c09789","article-title":"Photocatalyzed [2\u03c3\n+ 2\u03c3] and [2\u03c3 + 2\u03c0] Cycloadditions for the Synthesis\nof Bicyclo[3.1.1]Heptanes and 5- or 6-Membered Carbocycles","volume":"145","author":"Nguyen","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091425200_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202419426","article-title":"Photoredox Activation\nof Donor-Acceptor Cyclopropanes: Distonic Radical Cation Reactivity\nin [3 + 2] Cycloaddition Reactions","volume":"64","author":"Mondal","year":"2025","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026081410091425200_cit18","doi-asserted-by":"publisher","first-page":"27204","DOI":"10.1021\/jacs.4c11296","article-title":"Formal [2\u03c3\n+ 2\u03c3]-Cycloaddition of Aziridines with Bicyclo[1.1.0]Butanes:\nAccess to Enantiopure 2-Azabicyclo[3.1.1]Heptane Derivatives","volume":"146","author":"Dutta","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026081410091425200_cit19","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202404099","article-title":"Double\nStrain-Release (3 + 3)-Cycloaddition: Lewis Acid Catalyzed Reaction\nof Bicyclobutane Carboxylates and Aziridines","volume":"31","author":"George","year":"2025","journal-title":"Chem.\u2500Eur. J."},{"key":"2026081410091425200_cit20a","doi-asserted-by":"publisher","first-page":"19621","DOI":"10.1021\/jacs.4c01851","article-title":"Palladium-Catalyzed Ligand-Controlled\nSwitchable Hetero-(5 + 3)\/Enantioselective [2\u03c3+2\u03c3] Cycloadditions\nof Bicyclobutanes with Vinyl Oxiranes","volume":"146","author":"Zhou","year":"2024","journal-title":"J. Am.\nChem. Soc."},{"key":"2026081410091425200_cit20b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416741","article-title":"Ring Expansion toward Fused Diazabicyclo[3.1.1]Heptanes\nthrough Lewis Acid Catalyzed Highly Selective C-C\/C-N Bond Cross Exchange\nReaction between Bicyclobutanes and Diaziridines","volume":"64","author":"He","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit20c","doi-asserted-by":"publisher","first-page":"4430","DOI":"10.1039\/D5QO00460H","article-title":"Palladium-Catalyzed Double Strain-Release\n(3 + 3) Cycloaddition for the Synthesis of Vinylbicyclo[3.1.1]Heptanes","volume":"12","author":"Gao","year":"2025","journal-title":"Org. Chem. Front."},{"key":"2026081410091425200_cit21a","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1021\/jm501853m","article-title":"A Survey of the Role of Noncovalent\nSulfur Interactions in Drug Design","volume":"58","author":"Beno","year":"2015","journal-title":"J. Med.\nChem."},{"key":"2026081410091425200_cit21b","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1039\/C8NP00093J","article-title":"Construction of Sulfur-Containing Moieties in the Total Synthesis\nof Natural Products","volume":"37","author":"Wang","year":"2020","journal-title":"Nat. Prod. Rep."},{"key":"2026081410091425200_cit21c","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1080\/17460441.2022.2044783","article-title":"The Importance of Sulfur-Containing\nMotifs in Drug Design and Discovery","volume":"17","author":"Mustafa","year":"2022","journal-title":"Expert\nOpin. Drug Discovery"},{"key":"2026081410091425200_cit22a","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1038\/s41557-026-02097-7","article-title":"Collective\nSynthesis of 1,2,4-Trisubstituted, meta- and ortho-Substituted Arene\nBioisosteres from Bicyclobutanes","volume":"18","author":"Wu","year":"2026","journal-title":"Nat. Chem."},{"key":"2026081410091425200_cit22b","doi-asserted-by":"publisher","DOI":"10.1002\/ange.5228347","article-title":"Beyond para- and meta-Substitution:\nSynthesis and Biological Validation of Chalcogen-Rich Thiabicyclo[3.1.1]Heptanes\nas Bioisosteres of Aryl Thioether Derivatives","volume":"138","author":"Wang","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit22c","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/s41557-026-02072-2","article-title":"Hetero[3.1.1]Propellanes","volume":"18","author":"Revie","year":"2026","journal-title":"Nat. Chem."},{"key":"2026081410091425200_cit23a","doi-asserted-by":"publisher","first-page":"8588","DOI":"10.1039\/D5SC00125K","article-title":"(3 + 2)-Cycloaddition\nof Bicyclobutanes and Thioketones: Access to 2-Thiabicyclo[2.1.1]Hexanes\nwithout the Use of Catalysts or Light","volume":"16","author":"Knyazev","year":"2025","journal-title":"Chem.\nSci."},{"key":"2026081410091425200_cit23b","doi-asserted-by":"publisher","first-page":"7877","DOI":"10.1021\/acscatal.5c02274","article-title":"Lewis Acid-Catalyzed\nEnantioselective (4 + 3)\/Thia-(3 + 2) Cycloadditions of Bicyclobutanes\nand Enaminothiones: Catalyst Directed Divergent Synthesis of Bridged\nSulfur Heterocycles","volume":"15","author":"Tang","year":"2025","journal-title":"ACS Catal."},{"key":"2026081410091425200_cit24a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202484061","article-title":"Divergent\nSynthesis of Sulfur-Containing Bridged Cyclobutanes by Lewis Acid\nCatalyzed Formal Cycloadditions of Pyridinium 1,4 Zwitterionic Thiolates\nand Bicyclobutanes","volume":"63","author":"Xiao","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit24b","doi-asserted-by":"publisher","first-page":"7247","DOI":"10.1021\/acs.orglett.6c01731","article-title":"Lewis Acid-Catalyzed (3 + 3) Annulation of Bicyclo[1.1.0]Butanes\nwith Mercaptoacetaldehyde: Access to 2-Thiabicyclo[3.1.1]Heptanes","volume":"28","author":"Pal","year":"2026","journal-title":"Org. Lett."},{"key":"2026081410091425200_cit25a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202405222","article-title":"Switching between\nthe [2\u03c0+2\u03c3] and Hetero-[4\u03c0+2\u03c3] Cycloaddition\nReactivity of Bicyclobutanes with Lewis Acid Catalysts Enables the\nSynthesis of Spirocycles and Bridged Heterocycles","volume":"63","author":"Wang","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081410091425200_cit25b","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1021\/acs.orglett.5c00585","article-title":"Synthesis of 2,5-Dithia-Bicyclo[4.1.1]Octanes by Silver-Catalyzed\nFormal (4 + 3) Cycloadditions of Bicyclobutanes with Benzodithioloimines","volume":"27","author":"Zhou","year":"2025","journal-title":"Org. Lett."},{"key":"2026081410091425200_cit26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1126\/science.adh9737","article-title":"Dearomative\nRing Expansion\nof Thiophenes by Bicyclobutane Insertion","volume":"381","author":"Wang","year":"2023","journal-title":"Science"},{"key":"2026081410091425200_cit27","doi-asserted-by":"publisher","first-page":"7158","DOI":"10.1021\/acs.orglett.6c01548","article-title":"Lewis-Acid-Catalyzed\nCyclization of Bicyclo[1.1.0]Butanes with Alkenyl Cyclic Dithioacetals\nfor the Synthesis of 11-Membered Bicyclic Medium-Sized Rings","volume":"28","author":"Chen","year":"2026","journal-title":"Org. Lett."},{"key":"2026081410091425200_cit28","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1039\/C9MD00064J","article-title":"Synthesis\nof Bicyclic 1,4-Thiazepines as Novel Anti-Trypanosoma Brucei Brucei\nAgents","volume":"10","author":"Vairoletti","year":"2019","journal-title":"Med. Chem. Commun."},{"key":"2026081410091425200_cit29","doi-asserted-by":"publisher","first-page":"10159","DOI":"10.1039\/D6SC01258B","article-title":"Dimerisation of aryl-substituted\nbicyclobutanes (BCBs):\nrevealing a new mode of 1,3-dipolar background reactivity","volume":"17","author":"George","year":"2026","journal-title":"Chem. Sci."},{"key":"2026081410091425200_cit30","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1038\/s41467-023-38059-7","article-title":"Design of C1-symmetric tridentate\nligands for enantioselective dearomative [3 + 2] annulation of indoles\nwith aminocyclopropanes","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."}],"container-title":["Organic Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.6c02727","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/orlef7\/article-pdf\/28\/32\/10283\/66350324\/acs.orglett.6c02727.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/orlef7\/article-pdf\/28\/32\/10283\/66350324\/acs.orglett.6c02727.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:33:20Z","timestamp":1786718000000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/orlef7\/article\/28\/32\/10283\/5238067\/Construction-of-Bridged-Tricycles-by-Lewis-Acid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":86,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,7,31]]},"published-print":{"date-parts":[[2026,8,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.orglett.6c02727","relation":{},"ISSN":["1523-7060","1523-7052"],"issn-type":[{"value":"1523-7060","type":"print"},{"value":"1523-7052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}