{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:01:49Z","timestamp":1786719709256,"version":"build-2736575974"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300420758"],"award-info":[{"award-number":["252300420758"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["262300420599"],"award-info":[{"award-number":["262300420599"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014864","name":"Anyang Normal University","doi-asserted-by":"publisher","award":["2023AYSYKYCXTD03"],"award-info":[{"award-number":["2023AYSYKYCXTD03"]}],"id":[{"id":"10.13039\/501100014864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["262102310411"],"award-info":[{"award-number":["262102310411"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anyang City","award":["2026C01SF114"],"award-info":[{"award-number":["2026C01SF114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Synthetic strategies enabling the divergent synthesis of various product types from identical substrates are greatly favored in organic synthesis. In this work, we develop a switchable, metal-free strategy for the controllable synthesis of 1,5-benzodiazepines and quinoxaline-2-carbaldehydes via selective [4+3] and [4+2] cyclization of cyclopropanols with 1,2-diaminoarenes. Tunable product selectivity can be attributed to solvents that mediate divergent reaction pathways. The formation and stabilization of 1,5-benzodiazepines are promoted by HFIP, whereas further oxidation and isomerization into quinoxaline-2-carbaldehydes are facilitated by DMSO. Notably, this strategy not only provides a facile route to controllably synthesize valuable nitrogen heterocycles but also realizes diversified ring-opening transformations of cyclopropanols.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02743","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:21:47Z","timestamp":1785849707000},"page":"10290-10295","source":"Crossref","is-referenced-by-count":0,"title":["Solvent-Driven\nSwitchable Annulation of Cyclopropanols\nwith 1,2-Diaminoarenes Enables Divergent Synthesis of 1,5-Benzodiazepines\nand Quinoxaline-2-carbaldehydes"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2407-9513","authenticated-orcid":true,"given":"Jun-Long","family":"Zhan","sequence":"first","affiliation":[{"name":"Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University , ,","place":["Anyang, P. R. China, 455000"]},{"name":"Key Laboratory of New Optoelectronic Functional Materials , , ,","place":["Anyang, Henan, P. R. China, 455000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University , ,","place":["Anyang, P. R. China, 455000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University , ,","place":["Anyang, P. R. China, 455000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Wei","sequence":"additional","affiliation":[{"name":"Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University , ,","place":["Anyang, P. R. China, 455000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University , ,","place":["Anyang, P. R. China, 455000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoqiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University , ,","place":["Anyang, P. R. China, 455000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[{"name":"Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University , ,","place":["Anyang, P. R. China, 455000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6616-6953","authenticated-orcid":true,"given":"Wen-Jun","family":"Han","sequence":"additional","affiliation":[{"name":"Shangqiu Normal University , , ,","place":["Shangqiu, P. R. China, 476000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University , ,","place":["Anyang, P. R. China, 455000"]},{"name":"Key Laboratory of New Optoelectronic Functional Materials , , ,","place":["Anyang, Henan, P. R. 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