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Compound 1 features a unique 2-cyclopentane-bicyclo[3.3.0]octane scaffold, while 2 possesses a rare 2-cyclopentyltetrahydrofuran framework. Their absolute configurations were unequivocally determined by spectroscopic analysis, single-crystal X-ray diffraction, and ECD calculations. Remarkably, (+)-1 displayed potent antitubercular activity by selectively inhibiting the acetyltransferase domain of Mycobacterium tuberculosis GlmU through a dual mechanism, acting competitively against acetyl-CoA (Ki = 0.07 \u03bcM) and noncompetitively against glucosamine-1-phosphate (GlcN-1-P, Ki = 0.20 \u03bcM).<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02749","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:33:35Z","timestamp":1785854015000},"page":"10296-10301","source":"Crossref","is-referenced-by-count":3,"title":["Discovery of\nPolycyclic Polyprenylated Acylphloroglucinols\nfrom\n                    <i>Hypericum androsaemum<\/i>\n                    as Dual-Mechanism Inhibitors\nof\n                    <i>Mycobacterium tuberculosis<\/i>\n                    GlmU Acetyltransferase"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4395-9362","authenticated-orcid":true,"given":"Jiangchun","family":"Wei","sequence":"first","affiliation":[{"name":"Heping Hospital Affiliated to Changzhi Medical College , , ,","place":["Changzhi, China, 046000"]},{"name":"Changzhi Medical College , , ,","place":["Changzhi, China, 046000"]},{"name":"Heping Hospital Affiliated to Changzhi Medical College , , ,","place":["Changzhi, China, 046000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingpiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Changzhi Medical College , , ,","place":["Changzhi, China, 046000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology , , ,","place":["Wuhan, China, 430022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Fan","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology , , ,","place":["Wuhan, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Heping Hospital Affiliated to Changzhi Medical College , , ,","place":["Changzhi, China, 046000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology , , ,","place":["Wuhan, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Heping Hospital Affiliated to Changzhi Medical College , , ,","place":["Changzhi, China, 046000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Heping Hospital Affiliated to Changzhi Medical College , , ,","place":["Changzhi, China, 046000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-2142","authenticated-orcid":true,"given":"Yonghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology , , ,","place":["Wuhan, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1247-5615","authenticated-orcid":true,"given":"Zhengxi","family":"Hu","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology , , ,","place":["Wuhan, China, 430030"]},{"name":"Hubei Shizhen Laboratory , ,","place":["Wuhan, China, 430061"]},{"name":"Hubei University of Medicine , , ,","place":["Shiyan, China, 442000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026081410084867400_cit2","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/S0140-6736(19)30308-3","article-title":"Tuberculosis","volume":"393","author":"Furin","year":"2019","journal-title":"Lancet."},{"key":"2026081410084867400_cit3","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.3201\/eid2511.180638","article-title":"Drug-Susceptible\nand Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient","volume":"25","author":"Baffoe-Bonnie","year":"2019","journal-title":"Emerg. 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