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These enzymes operate in two modes: autonomous cyclization to produce structurally diverse terpenes, including unprecedented diterpenes and the first bacterial UbiA-derived sesquiterpenes; and cooperation with type II TSs to replace canonical type I enzymes. Downstream tailoring further diversifies UbiA-derived scaffolds. This work provides a genomic framework for the terpenoid discovery.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02777","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:02:11Z","timestamp":1786712531000},"page":"10725-10730","source":"Crossref","is-referenced-by-count":1,"title":["Genome Mining\nReveals Widespread Catalytic Modes and\nChemical Diversity of Bacterial UbiA-Type Terpene Synthases"],"prefix":"10.1021","volume":"28","author":[{"given":"Wan Xin","family":"Chen","sequence":"first","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Ling","family":"Hu","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Ling","family":"Huang","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang Zhou","family":"Yin","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-6488","authenticated-orcid":true,"given":"Zheng Ren","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-8700","authenticated-orcid":true,"given":"Ren Xiang","family":"Tan","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-808X","authenticated-orcid":true,"given":"Hui Ming","family":"Ge","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"2026090200203472000_cit1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1039\/D0NP00066C","article-title":"Bacterial Terpenome","volume":"38","author":"Rudolf","year":"2021","journal-title":"Nat. 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