{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:43:50Z","timestamp":1793105030985,"version":"4.5.0"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22361162605"],"award-info":[{"award-number":["22361162605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2025NSCQ-GPX0691"],"award-info":[{"award-number":["CSTB2025NSCQ-GPX0691"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Key Laboratory of Neurology and Oncology Drug Development","doi-asserted-by":"publisher","award":["SKLSIM-20251128"],"award-info":[{"award-number":["SKLSIM-20251128"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Scientific Research Innovation Capability Support Project for Young Faculty","doi-asserted-by":"publisher","award":["ZYGXQNJSKYCXNLZCXM-H24"],"award-info":[{"award-number":["ZYGXQNJSKYCXNLZCXM-H24"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a DNA-compatible linchpin strategy for the construction and late-stage diversification of macrocyclic peptide DNA-encoded libraries (MPDELs). Treatment of DNA-conjugated linear peptides with 1,5-dichloropentane-2,4-dione (DPD) enabled highly efficient macrocyclization while introducing a versatile 1,3-diketone linchpin. Subsequent DNA-compatible late-stage diversification afforded four classes of heterocycle-embedded DNA-conjugated macrocycles, including pyrazoles, azolopyrimidines, 2-aminonicotinamides, and 2-hydroxynicotinonitriles, with a broad substrate scope and high conversion. A scale-up test, cross-substrate scope study, and enzymatic ligation demonstrated excellent compatibility with DNA-encoded library synthesis, providing a versatile platform for expanding the chemical space of macrocyclic peptide DNA-encoded libraries.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02792","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T12:57:43Z","timestamp":1784465863000},"page":"9811-9816","source":"Crossref","is-referenced-by-count":2,"title":["A Diketone Linchpin\nStrategy for On-DNA Macrocyclization\nand Late-Stage Diversification"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-6852","authenticated-orcid":true,"given":"Qigui","family":"Nie","sequence":"first","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 408000"]},{"name":"Chongqing University , , ,","place":["Chongqing, China, 401331"]},{"name":"The State Key Laboratory of Neurology and Oncology Drug Development , ,","place":["Nanjing, China, 210042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshan","family":"Fan","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-9340","authenticated-orcid":true,"given":"Xianfu","family":"Fang","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 401331"]},{"name":"Chongqing University , , ,","place":["Chongqing, China, 404100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Yang","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-176X","authenticated-orcid":true,"given":"Gong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-6154","authenticated-orcid":true,"given":"Yangfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-3780","authenticated-orcid":true,"given":"Yizhou","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"2026073109274900700_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308251","article-title":"Cyclic peptides for drug development","volume":"63","author":"Ji","year":"2024","journal-title":"Angew. 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