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The cleavage proceeds under mild conditions with short reaction times and is operationally simple. We have demonstrated the utility of this transformation for the protection of common functional groups as 3-Pic derivatives; for amines, we also applied protection as the 3-picolyloxycarbonyl group. Readily available reagents, combined with their unique selectivity, render this transformation a versatile addition to the organic chemist\u2019s protecting group toolbox.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02800","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:02:18Z","timestamp":1787083338000},"page":"10737-10742","source":"Crossref","is-referenced-by-count":0,"title":["Selectride-Mediated\nCleavage of 3-Picolyl and\n3-Picolyloxycarbonyl Groups"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2622-8254","authenticated-orcid":true,"given":"Lorenz","family":"Urner","sequence":"first","affiliation":[{"name":"F. Hoffmann-La Roche, Limited , , ,","place":["Basel, Switzerland, 4070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Kym","sequence":"additional","affiliation":[{"name":"F. 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Hoffmann-La Roche, Limited , , ,","place":["Basel, Switzerland, 4070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-4325","authenticated-orcid":true,"given":"Christian","family":"Bartelmus","sequence":"additional","affiliation":[{"name":"F. Hoffmann-La Roche, Limited , , ,","place":["Basel, Switzerland, 4070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Wyss","family":"Gramberg","sequence":"additional","affiliation":[{"name":"F. Hoffmann-La Roche, Limited , , ,","place":["Basel, Switzerland, 4070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Steinbrecher","sequence":"additional","affiliation":[{"name":"F. 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