{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:10:30Z","timestamp":1785507030293,"version":"3.56.0"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22401049"],"award-info":[{"award-number":["22401049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A photocatalyst-free radical SN2\u2032-type alkylation of gem-dichlorocyclobutenones with unactivated alkenes is enabled by visible-light-induced C\u2013Zr bond homolysis. Alkylzirconium intermediates generated in situ from terminal or internal alkenes serve as alkyl radical precursors and undergo radical addition\/\u03b2-fragmentation with gem-dichlorocyclobutenones to afford ring-retained \u03b1-chlorocyclobutenones. This protocol avoids preformed radical donors and external photocatalysts, proceeds under mild conditions, tolerates structurally complex substrates, and furnishes multifunctional \u03b1-chlorocyclobutenones suitable for further diversification.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02820","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:19:42Z","timestamp":1784607582000},"page":"9823-9827","source":"Crossref","is-referenced-by-count":0,"title":["Ring-Retentive\nSN2\u2032-Type Alkylation\nof\n                    <i>gem<\/i>\n                    -Dichlorocyclobutenones Enabled by an\n                    <i>In Situ<\/i>\n                    Alkene-to-Radical Relay"],"prefix":"10.1021","volume":"28","author":[{"given":"Zexu","family":"Su","sequence":"first","affiliation":[{"name":"Fuzhou University , , ,","place":["Fuzhou, China, 350108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Han","sequence":"additional","affiliation":[{"name":"Fuzhou University , , ,","place":["Fuzhou, China, 350108"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3905-4535","authenticated-orcid":true,"given":"Huifeng","family":"Yue","sequence":"additional","affiliation":[{"name":"Fuzhou University , , ,","place":["Fuzhou, China, 350108"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"2026073109270907100_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202200020","article-title":"Cyclobutanes in Small-Molecule Drug Candidates","volume":"17","author":"van der Kolk","year":"2022","journal-title":"ChemMedChem."},{"key":"2026073109270907100_cit2","doi-asserted-by":"publisher","first-page":"7513","DOI":"10.1039\/D0CS01396J","article-title":"Small rings in the bigger picture: ring expansion of\nthree- and four-membered rings to access larger all-carbon cyclic\nsystems","volume":"50","author":"Biletskyi","year":"2021","journal-title":"Chem. 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