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[IrCp*Cl2]2 catalyzed intramolecular cyclization of amino-hydroxy-amides via borrowing hydrogenation, afforded therapeutically beneficial 1,4-benzodiazepin-5-ones. A plausible mechanism for both steps has been elucidated. The 1,4-benzodiazepin-5-one frameworks were structurally diversified through postsynthetic modification. This protocol enables access to natural products such as Circumdatin F and Circumdatin H, further underscoring its potential.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02844","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:08:47Z","timestamp":1787242127000},"page":"10930-10935","source":"Crossref","is-referenced-by-count":0,"title":["From Esters\nto Benzodiazepines: A Two-Step Nickel\u2013Iridium\nCatalytic Pathway via Amide Intermediates"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8079-6451","authenticated-orcid":true,"given":"Gourishankar B.","family":"Swami","sequence":"first","affiliation":[{"name":"Indian Institute of Science Education and Research , , , ,","place":["Pune, Maharashtra, India, 411008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmavathy V. 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