{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:00:57Z","timestamp":1786719657729,"version":"build-2736575974"},"reference-count":14,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The synthesis of multiple antigenic peptides (MAPs) remains challenging and is conventionally achieved by using Lys-based branching cores. However, the presence of two asymmetric amino groups in Lys results in the formation of multiple isomeric impurities. To address this limitation, a novel symmetrical branching unit based on s-triazine, Fmoc2-TBM-OH (TBM for triazine-bis-multipod, 1), was synthesized and applied in MAP synthesis. The TBM-based strategy enabled efficient four-copy MAP synthesis and produced a less complex impurity profile, demonstrating improved robustness, chromatographic behavior, and synthetic practicality.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02863","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:37:42Z","timestamp":1785854262000},"page":"10328-10332","source":"Crossref","is-referenced-by-count":0,"title":["Symmetrical\nBranching Unit Alternative to Lysine-Core-Based\nMultiple Antigenic Peptides to Eradicate Isomeric Impurities"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1282-5838","authenticated-orcid":true,"given":"Anamika","family":"Sharma","sequence":"first","affiliation":[{"name":"University of KwaZulu-Natal , , , ,","place":["Durban, KwaZulu-Natal, South Africa, 4001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica T.","family":"Mhlongo","sequence":"additional","affiliation":[{"name":"University of KwaZulu-Natal , , , ,","place":["Durban, KwaZulu-Natal, South Africa, 4001"]},{"name":"University of KwaZulu-Natal , , , ,","place":["Durban, KwaZulu-Natal, South Africa, 4041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edikarlos","family":"Brasil","sequence":"additional","affiliation":[{"name":"University of KwaZulu-Natal , , , ,","place":["Durban, KwaZulu-Natal, South Africa, 4001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Willig","sequence":"additional","affiliation":[{"name":"Bachem AG , Hauptstra\u00dfe 144 , ,","place":["Bubendorf, Switzerland, 4416"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-0951","authenticated-orcid":true,"given":"Ralph","family":"Scho\u0308nleber","sequence":"additional","affiliation":[{"name":"Bachem AG , Hauptstra\u00dfe 144 , ,","place":["Bubendorf, Switzerland, 4416"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-0462","authenticated-orcid":true,"given":"Fernando","family":"Albericio","sequence":"additional","affiliation":[{"name":"University of KwaZulu-Natal , , , ,","place":["Durban, KwaZulu-Natal, South Africa, 4001"]},{"name":"University of Barcelona , , Marti\u0301 i Franque\u0301s 1-11 , , ,","place":["Barcelona, Barcelona, Spain, 08028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-9172","authenticated-orcid":true,"given":"Beatriz G.","family":"de la Torre","sequence":"additional","affiliation":[{"name":"University of KwaZulu-Natal , , , ,","place":["Durban, KwaZulu-Natal, South Africa, 4001"]},{"name":"University of KwaZulu-Natal , , , ,","place":["Durban, KwaZulu-Natal, South Africa, 4041"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"15","key":"2026081410092416400_cit1","doi-asserted-by":"publisher","first-page":"5409","DOI":"10.1073\/pnas.85.15.5409","article-title":"Synthetic\npeptide vaccine design: synthesis and properties of a high-density\nmultiple antigenic peptide system","volume":"85","author":"Tam","year":"1988","journal-title":"Proc. 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