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Moreover, this unexpected strategy could be strategically applied to divergently forge functionalized pyridines via two-step, one-pot protocols involving traceless C\u2013H activation. Notably, a CFTR potentiator (UCCF-29) could be readily prepared in 67% overall yield through this chemistry, achieving a 36% increase in yield relative to those with current methods. Mechanistic studies reveal that intramolecular hydrogen bonding is the driving force for the observed regio- and stereoselectivity. 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