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The cross-coupling of alcohols with acetone provides alkylated ketones in high yields, followed by selective \u03b1-alkylation with diverse alcohols to afford unsymmetrical diarylheptanoid precursors. This approach features a broad substrate scope and good functional group tolerance and is demonstrated through the concise synthesis of several natural diarylheptanoids, including Acerogenin C, Acerogenin G, Engelhardione, Muricarpone, Yakuchinone, and Pterocarine derivatives.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02877","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T19:14:15Z","timestamp":1788203655000},"page":"10936-10941","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of\nDiarylheptanoids Using Acetone and Alcohols\nvia a Catalytic Borrowing Alkylation Strategy"],"prefix":"10.1021","volume":"28","author":[{"given":"Abhijit V.","family":"More","sequence":"first","affiliation":[{"name":"Indian Institute of Science Education and Research , , ,","place":["Pune, India, 411008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhakti M.","family":"Bate","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research , , ,","place":["Pune, India, 411008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashrat Vishambar","family":"Sutar","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research , , ,","place":["Pune, India, 411008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallob Jyoti","family":"Das","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research , , ,","place":["Pune, India, 411008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-9636","authenticated-orcid":true,"given":"Boopathy","family":"Gnanaprakasam","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research , , ,","place":["Pune, India, 411008"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026090409103394900_cit1a","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1016\/S0968-0896(02)00164-5","article-title":"Chemopreventive Potential\nof Cyclic Diarylheptanoids","volume":"10","author":"Ishida","year":"2002","journal-title":"Bioorg. 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