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A diverse set of RNHOH derivatives, including amino-acid- and carbohydrate-based substrates, undergo efficient coupling with BCN to furnish the corresponding nitrones in good yields. Comparison of several cyclooctynes highlights substantial differences in reactivity, with DBCO-acid displaying the fastest reaction (k2 &amp;gt; 23 M\u20131 s\u20131). The resulting nitrones can subsequently participate in strain-promoted alkyne\u2013nitrone cycloaddition (SPANC) reactions, enabling a sequential \u201cclick-to-click\u201d ligation of up to three components.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02899","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:58:27Z","timestamp":1784282307000},"page":"9834-9839","source":"Crossref","is-referenced-by-count":0,"title":["Toward a Click-to-Click\nStrategy Enabled by Sequential\nReverse Cope Cyclization and Strain-Promoted Alkyne\u2013Nitrone\nCycloaddition of\n                    <i>In Situ<\/i>\n                    Generated Nitrones"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-9643","authenticated-orcid":true,"given":"Vivien","family":"Herrscher","sequence":"first","affiliation":[{"name":"Universite\u0301 de Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Martinez","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687"]},{"name":"Universite\u0301 de Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Valle\u0301e","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687"]},{"name":"Universite\u0301 de Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-582X","authenticated-orcid":true,"given":"Anthony","family":"Abou Dib","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687"]},{"name":"Universite\u0301 de Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-8806","authenticated-orcid":true,"given":"Jean-Bernard","family":"Behr","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"issue":"38","key":"2026073109271255900_cit1","doi-asserted-by":"publisher","first-page":"6974","DOI":"10.1002\/anie.200900942","article-title":"Bioorthogonal Chemistry: Fishing for Selectivity in\na Sea of Functionality","volume":"48","author":"Sletten","year":"2009","journal-title":"Angew. 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