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Herein, we report a time-dependent cascade reaction for the synthesis of bicyclic [5.3.0]decanes and dihydronaphthyl-2-one derivatives. By simply tuning the reaction time, two distinct types of products are selectively obtained from identical substrates under identical conditions. This method features mild conditions, step economy, and broad substrate compatibility, with its synthetic potential validated by scale-up, derivatization, and late-stage functionalization.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c02936","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:07:36Z","timestamp":1787242056000},"page":"10961-10966","source":"Crossref","is-referenced-by-count":0,"title":["Cascade Reaction\nof Barbiturate Heptafulvenes with\nAcetic Acid Esters"],"prefix":"10.1021","volume":"28","author":[{"given":"Chengli","family":"Mou","sequence":"first","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Normal University , , ,","place":["Fuzhou, China, 350117"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Normal University , , ,","place":["Fuzhou, China, 350117"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Normal University , , ,","place":["Fuzhou, China, 350117"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-8847","authenticated-orcid":true,"given":"Shoulei","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Normal University , , ,","place":["Fuzhou, China, 350117"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"2026090409093954600_cit1a","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1039\/C8NP00078F","article-title":"Tropolone\nnatural products","volume":"36","author":"Guo","year":"2019","journal-title":"Nat. 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