{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:11:37Z","timestamp":1789139497658,"version":"build-2803163510"},"reference-count":28,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M722849"],"award-info":[{"award-number":["2022M722849"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016087","name":"Qufu Normal University","doi-asserted-by":"publisher","award":["6147"],"award-info":[{"award-number":["6147"]}],"id":[{"id":"10.13039\/100016087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QB015"],"award-info":[{"award-number":["ZR2020QB015"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2026MS0186"],"award-info":[{"award-number":["ZR2026MS0186"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011245","name":"State Key Laboratory of Coordination Chemistry","doi-asserted-by":"publisher","award":["SKLCC2404"],"award-info":[{"award-number":["SKLCC2404"]}],"id":[{"id":"10.13039\/501100011245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a palladium-catalyzed C\u2013H thiolation of phenylalanine residues in peptides using diaryl disulfides. Key to this approach is an imine directing group generated in situ from the N-terminal Boc group, which obviates the need for an external auxiliary. The reaction features a broad substrate scope, good functional group tolerance, and scalability, delivering thioether-functionalized peptides in synthetically useful yields. Mechanistic studies suggest an imine-directed C\u2013H activation followed by radical C\u2013S bond formation. This auxiliary-free strategy, which relies on a substrate-derived imine as the directing group, provides a versatile platform for late-stage peptide modifications.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03047","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:44:48Z","timestamp":1788320688000},"page":"11243-11251","source":"Crossref","is-referenced-by-count":0,"title":["Palladium-Catalyzed\nC\u2013H Thiolation of Phenylalanine-Containing\nPeptides via In Situ Imine Generation"],"prefix":"10.1021","volume":"28","author":[{"given":"Qinyu","family":"Lu","sequence":"first","affiliation":[{"name":"Qufu Normal University , , ,","place":["Qufu, P. R. China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Fu","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , ,","place":["Qufu, P. R. 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