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Herein, we report a concise synthesis of tropono-\u03b22,3-amino acid derivatives from readily available phenols and nitriles via oxidative dearomatization followed by a one-pot Michael addition\/retro-6\u03c0 electrocyclization\/oxidation sequence. Control experiments and DFT calculations indicate a kinetically controlled ring expansion followed by rapid [1,5]-H shift leading to the thermodynamically favored anionic intermediate.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03049","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:02:39Z","timestamp":1786377759000},"page":"10609-10614","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of\nTropono-\u03b22,3-Amino\nAcid Derivatives via Benzene-to-Tropone Skeletal Editing"],"prefix":"10.1021","volume":"28","author":[{"given":"Hui-Qing","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences , , ,","place":["Shanghai, China, 201203"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences , , ,","place":["Shanghai, China, 201203"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-2056","authenticated-orcid":true,"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences , , ,","place":["Shanghai, China, 201203"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026082212102963100_cit1a","doi-asserted-by":"publisher","first-page":"9281","DOI":"10.1016\/j.tet.2014.07.065","article-title":"Synthesis\nof Naturally Occurring\nTropones and Tropolones","volume":"70","author":"Liu","year":"2014","journal-title":"Tetrahedron"},{"key":"2026082212102963100_cit1b","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1039\/D3NP00067B","article-title":"Cephalotane Diterpenoids:\nStructural Diversity, Biological Activity, Biosynthetic Proposal,\nand Chemical Synthesis","volume":"41","author":"Zhao","year":"2024","journal-title":"Nat. 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