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Extensive mechanistic studies reveal distinct concerted and stepwise pathways. This one-pot, one-step protocol proceeds under mild, metal-free conditions, releasing only N2 and methanol as byproducts, which also provides a rare example of condition-controlled divergent ring manipulation of \u03b2-lactams via C3\u2013C4 bond cleavage.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03051","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:02:00Z","timestamp":1786964520000},"page":"10809-10815","source":"Crossref","is-referenced-by-count":0,"title":["Divergent C3\u2013C4\nBond Cleavage of Spiro \u03b2-Lactams\nfor the Switchable Synthesis of 3,3-Disubstituted Oxindoles and 2-Arylacrylamides"],"prefix":"10.1021","volume":"28","author":[{"given":"Yuanxin","family":"Liu","sequence":"first","affiliation":[{"name":"Wuhan University of Technology , , ,","place":["Wuhan, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanrui","family":"Liu","sequence":"additional","affiliation":[{"name":"Wuhan University of Technology , , ,","place":["Wuhan, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Shu","sequence":"additional","affiliation":[{"name":"Wuhan University of Technology , , ,","place":["Wuhan, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaxia","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemistry for NBC Hazards Protection , ,","place":["Beijing, China, 102205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9760-0251","authenticated-orcid":true,"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan University of Technology , , ,","place":["Wuhan, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026090200202260500_cit1a","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1021\/acs.chemrev.7b00653","article-title":"Divergent\nStrategy in Natural Product Total Synthesis","volume":"118","author":"Li","year":"2018","journal-title":"Chem. 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