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This protocol features a broad substrate scope, high functional group tolerance, operational simplicity, and scalability. Mechanistic studies reveal that N-phenylhydroxylamine plays a key role in facilitating the radical relay process. Furthermore, the late-stage functionalization of biologically relevant molecules highlights the synthetic utility of this method for the preparation of structurally diverse \u03b1-CF3 ketones.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03090","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:01:58Z","timestamp":1786968118000},"page":"10822-10826","source":"Crossref","is-referenced-by-count":0,"title":["<i>N<\/i>\n                    -Phenylhydroxylamine-Induced\nRadical Relay for the Synthesis of \u03b1-Trifluoromethyl\nKetones"],"prefix":"10.1021","volume":"28","author":[{"given":"Rui-Qiang","family":"Jiao","sequence":"first","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changping","family":"Tian","sequence":"additional","affiliation":[{"name":"Shandong University , , 27 South Shanda Road , , ,","place":["Ji\u2019nan, Shandong, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4049-6832","authenticated-orcid":true,"given":"Hongyin","family":"Gao","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]},{"name":"Shandong University , , 27 South Shanda Road , , ,","place":["Ji\u2019nan, Shandong, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026090200165891300_cit1a","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1021\/op700134j","article-title":"Fluorination in Medicinal Chemistry: Methods, Strategies,\nand Recent Developments","volume":"12","author":"Kirk","year":"2008","journal-title":"Org. 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