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We have developed a metal-free dearomatization\/rearomatization strategy using readily available isocyanates as nitrogen source. Inexpensive DMAD serves as the dearomative reagent to form intermediates, which are rearomatized by DBU to afford 2-aminopyridines. The protocol offers good functional-group tolerance, operational simplicity, and scalability. It extends to quinolines and isoquinolines, and allows late-stage functionalization of complex biomolecules.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03164","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:44:25Z","timestamp":1788191065000},"page":"11070-11075","source":"Crossref","is-referenced-by-count":0,"title":["Direct 2-Amination\nof Pyridines via Dearomatization\/Rearomatization\nStrategy"],"prefix":"10.1021","volume":"28","author":[{"given":"Shuaiyu","family":"Chen","sequence":"first","affiliation":[{"name":"Zhejiang Normal University , , 688 Yingbin Road , ,","place":["Jinhua, China, 321004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhejiang Normal University , , 688 Yingbin Road , ,","place":["Jinhua, China, 321004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingru","family":"Song","sequence":"additional","affiliation":[{"name":"Zhejiang Normal University , , 688 Yingbin Road , ,","place":["Jinhua, China, 321004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Normal University , , 688 Yingbin Road , ,","place":["Jinhua, China, 321004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9560-6296","authenticated-orcid":true,"given":"Xi-Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Normal University , , 688 Yingbin Road , ,","place":["Jinhua, China, 321004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Normal University , , 688 Yingbin Road , ,","place":["Jinhua, China, 321004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-8934","authenticated-orcid":true,"given":"Xiaoli","family":"Han","sequence":"additional","affiliation":[{"name":"Zhejiang Normal University , , 688 Yingbin Road , ,","place":["Jinhua, China, 321004"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026090409095084700_cit1a","doi-asserted-by":"publisher","first-page":"10257","DOI":"10.1021\/jm501100b","article-title":"Analysis\nof the Structural Diversity, Substitution Patterns, and Frequency\nof Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. 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