{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:19:10Z","timestamp":1788326350416,"version":"build-2803163510"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr?det","doi-asserted-by":"publisher","award":["2024-03955"],"award-info":[{"award-number":["2024-03955"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005753","name":"Kungliga Fysiografiska S?llskapet i Lund","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100005753","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Herein, we report a concise formal synthesis of (\u00b1)-isoalantolactone through a six-step route to the advanced intermediate of Tada. The 5\/6\/6-fused eudesmanolide core is assembled through a SmI2-mediated reductive lactonization, while a late-stage acid-promoted sequence combines global deprotection, intramolecular aldol condensation, and thermodynamic stereochemical convergence to establish the required relative stereochemistry. Computational analysis supports thermodynamically controlled formation of the observed diastereomer and validates the overall synthetic design.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03173","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:02:29Z","timestamp":1787126549000},"page":"10859-10863","source":"Crossref","is-referenced-by-count":0,"title":["Formal Total\nSynthesis of (\u00b1)-Isoalantolactone"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7045-4880","authenticated-orcid":true,"given":"Wilma","family":"Olsson","sequence":"first","affiliation":[{"name":"Lund University , , ,","place":["Lund, Sweden, SE-221 00"]},{"name":"RG Discovery , Medicon Village ,","place":["Lund, Sweden, SE-221 81"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-7935","authenticated-orcid":true,"given":"Johan","family":"Wennerberg","sequence":"additional","affiliation":[{"name":"Lund University , , ,","place":["Lund, Sweden, SE-221 00"]},{"name":"RG Discovery , Medicon Village ,","place":["Lund, Sweden, SE-221 81"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7431-0886","authenticated-orcid":true,"given":"Sebastian","family":"Clementson","sequence":"additional","affiliation":[{"name":"Lund University , , ,","place":["Lund, Sweden, SE-221 00"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"15","key":"2026090200194140400_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e35270","article-title":"Eudesmane-Type\nSesquiterpenoids: Structural Diversity and Biological Activity","volume":"10","author":"Wu","year":"2024","journal-title":"Heliyon"},{"issue":"17","key":"2026090200194140400_cit2","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1080\/14786419.2018.1543676","article-title":"Active Ingredients of Inula Helenium L. 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ChemRxiv2025,10.26434\/chemrxiv-2025-694w3-v2.","DOI":"10.26434\/chemrxiv-2025-694w3-v2"},{"issue":"25","key":"2026090200194140400_cit22","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.1016\/S0040-4020(01)89024-4","article-title":"Synthesis of (+)-Isoalantolactone\nand (+)-Isoalloalantolactone from (\u2212)-Santonin","volume":"48","author":"Blay","year":"1992","journal-title":"Tetrahedron"},{"issue":"16","key":"2026090200194140400_cit23","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1016\/S0040-4020(01)97472-1","article-title":"A Highly Stereoselective\nTotal Synthesis of (\u00b1)-Isoalantolactone","volume":"30","author":"Miller","year":"1974","journal-title":"Tetrahedron"},{"key":"2026090200194140400_cit24","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1039\/P19930000239","article-title":"Total Synthesis\nof Three Eudesman-12,8-Olides, (\u00b1)-Isoalantolactone, (\u00b1)-Dihydrocallitrisin\nand (\u00b1)-Septuplinolide; Structure Revision of Septuplinolide","volume":"2","author":"Tada","year":"1993","journal-title":"J. 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