{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:03:20Z","timestamp":1789751000240,"version":"4.0.1"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22101188"],"award-info":[{"award-number":["22101188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22461036"],"award-info":[{"award-number":["22461036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bicyclo[n.1.1] skeletons are valuable bioisosteres for aromatic rings in drug discovery, yet efficient and versatile asymmetric synthesis of chiral azabicyclo[2.1.1]hexanes (aza-BCHs) remains challenging. To address the unexploited cycloaddition strategy involving oxazepines and bicyclo[1.1.0]butanes (BCBs), we develop a chiral-at-metal Rh(III)-catalyzed enantioselective (3 + 2) cycloaddition. This protocol affords diverse chiral aza-BCH derivatives in 50\u201396% yields with up to 99% ee under mild conditions, providing facile access to such privileged three-dimensional skeletons. In addition, a scale-up experiment and the synthetic transformations of the cycloadducts further highlight the synthetic utility.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03221","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:26:48Z","timestamp":1788452808000},"page":"11607-11612","source":"Crossref","is-referenced-by-count":0,"title":["Enantioselective\n(3 + 2) Cycloaddition of Oxazepines\nand Bicyclo[1.1.0]butanes Catalyzed by Chiral-at-Metal Rh(III) Complexes"],"prefix":"10.1021","volume":"28","author":[{"given":"Shijie","family":"Zhu","sequence":"first","affiliation":[{"name":"Shihezi University , , , ,","place":["Shihezi, Xinjiang, China, 832003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Xinjiang Second Medical College , , , ,","place":["Karamay, Xinjiang Uygur Autonomous Region, People\u2019s Republic of China, 834000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-0400","authenticated-orcid":true,"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Shihezi University , , , ,","place":["Shihezi, Xinjiang, China, 832003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5583-0729","authenticated-orcid":true,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shihezi University , , , ,","place":["Shihezi, Xinjiang, China, 832003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shihezi University , , , ,","place":["Shihezi, Xinjiang, China, 832003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Chuan","family":"Li","sequence":"additional","affiliation":[{"name":"Fuyang Normal University , , ,","place":["Fuyang, PR China, 236037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakun","family":"Sun","sequence":"additional","affiliation":[{"name":"Shihezi University , , , ,","place":["Shihezi, Xinjiang, China, 832003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-8108","authenticated-orcid":true,"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Shihezi University , , ,","place":["Shihezi, China, 832003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-0140","authenticated-orcid":true,"given":"Shi-Wu","family":"Li","sequence":"additional","affiliation":[{"name":"Shihezi University , , , ,","place":["Shihezi, Xinjiang, China, 832003"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026091809430884800_cit1","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1039\/C8OB02812E","article-title":"Saturated\nbioisosteres of benzene: where to go next?","volume":"17","author":"Mykhailiuk","year":"2019","journal-title":"Org. 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Chem."},{"key":"2026091809430884800_cit5","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1039\/c2md20347b","article-title":"Escape from\nFlatland 2: complexity and promiscuity","volume":"4","author":"Lovering","year":"2013","journal-title":"Med.\nChem. Commun."},{"key":"2026091809430884800_cit6","doi-asserted-by":"publisher","first-page":"20515","DOI":"10.1002\/anie.202004183","article-title":"Saturated bioisosteres of ortho-substituted\nbenzenes","volume":"59","author":"Denisenko","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026091809430884800_cit7","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/s41557-023-01222-0","article-title":"2-Oxabicyclo[2.1.1]hexanes\nas saturated\nbioisosteres of the ortho-substituted phenyl ring","volume":"15","author":"Denisenko","year":"2023","journal-title":"Nat. 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Front."},{"key":"2026091809430884800_cit40a","doi-asserted-by":"publisher","first-page":"18565","DOI":"10.1021\/jacs.4c04485","article-title":"Synthesis of Azabicyclo[3.1.1]heptenes Enabled by Catalyst-Controlled\nAnnulations of Bicyclo[1.1.0]butanes with Vinyl Azides","volume":"146","author":"Lin","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026091809430884800_cit40b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.6606811","article-title":"Photocatalytic Radical-Polar Crossover\nEnables Modular Access to Bicyclo[2.m.n]Alkane Alcohol Bioisosteres","volume":"65","author":"Ran","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026091809430884800_cit40c","doi-asserted-by":"publisher","first-page":"11908","DOI":"10.1039\/D5SC02836A","article-title":"Photocatalytic synthesis of 2-oxabicyclo[2.1.1]hexanes:\ncobalt-enhanced efficiency","volume":"16","author":"Tang","year":"2025","journal-title":"Chem. 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