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Nevertheless, the oxidative four-component synthesis of N-\u03b1-functionalized amides from alcohols, amines, carboxylic acids, and nucleophiles remains highly challenging, mainly due to the fact that this reaction involves multiple potentially oxidizable intermediates and reactants. Herein, this four-component reaction has been developed by employing a catalytic loading of TPAP alongside stoichiometric quantities of NMO serving as a terminal oxidant. The multicomponent approach demonstrates broad substrate scope and good functional group compatibility. The practicality of the protocol has been illustrated by the scalable synthesis and the late-stage functionalization of pharmaceuticals.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03224","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:24:51Z","timestamp":1788495891000},"page":"11601-11606","source":"Crossref","is-referenced-by-count":0,"title":["A One-Pot Synthesis\nof\n                    <i>N<\/i>\n                    -\u03b1-Functionalized\nAmides via Oxidative Four-Component Reaction of Alcohols, Amines,\nCarboxylic Acids, and Nucleophiles"],"prefix":"10.1021","volume":"28","author":[{"given":"Fang-Zhuo","family":"Wang","sequence":"first","affiliation":[{"name":"Zunyi Medical University , , ,","place":["Zunyi, P. R. China, 563006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Biao","family":"Chen","sequence":"additional","affiliation":[{"name":"Zunyi Medical University , , ,","place":["Zunyi, P. R. 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