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Herein, we disclose an Fe-catalyzed reductive defluorinative cross-coupling between trifluoromethyl alkenes and 1,3-dioxolanyl- or 1,3-dioxepanyl-substituted alkyl iodides, enabling the rapid assembly of five- or seven-membered cyclic acetal-embodied fluorinated scaffolds, respectively. This protocol enriches defluorinative coupling versatility and offers streamlined access to structurally diverse pharmaceutically relevant scaffolds.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03239","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:01:43Z","timestamp":1790096503000},"page":"12195-12201","source":"Crossref","is-referenced-by-count":0,"title":["Iron-Catalyzed\nDefluorinative Alkylation for Accessing\nCyclic Acetal\u2013\n                    <i>gem<\/i>\n                    -Difluoroalkenes"],"prefix":"10.1021","volume":"28","author":[{"given":"Xiao-Tong","family":"Wang","sequence":"first","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["Shatin, New Territories, Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-0110","authenticated-orcid":true,"given":"Pui Ying","family":"Choy","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["Shatin, New Territories, Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-0767","authenticated-orcid":true,"given":"Chi Wai","family":"Cheung","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["Shatin, New Territories, Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9105-1740","authenticated-orcid":true,"given":"Fuk Yee","family":"Kwong","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["Shatin, New Territories, Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"2026100208371592600_cit1a","doi-asserted-by":"publisher","first-page":"5822","DOI":"10.1021\/acs.jmedchem.7b01788","article-title":"Fluorine and Fluorinated\nMotifs in the Design and Application\nof Bioisosteres for Drug Design","volume":"61","author":"Meanwell","year":"2018","journal-title":"J. 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