{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:59:43Z","timestamp":1790348383064,"version":"4.1.0"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Four unprecedented cytochalasins, boereguasins A\u2013D (1\u20134, respectively), were purified from the endophytic fungus Boeremia exigua. Structurally, compound 1 contains an adenosine moiety and features a novel bridged 5\/6\/13\/5\/6\/5 ring system. Compound 2 represents the first cytochalasin with an odd-numbered carbon chain (19 carbons), which is presumably assembled via the fungal polyketide synthase pathway from an unusual propionyl-CoA starter unit. Compound 3 incorporates an unusual 15-membered carbocyclic ring, while compound 4 possesses a novel 5\/6\/14\/6 tetracyclic scaffold. The structures were established by comprehensive spectroscopic analysis, ECD calculations, and DP4+ analysis. Compound 2 exhibited potent anti-inflammatory activity in LPS-induced RAW264.7 macrophages, significantly reducing NO, TNF-\u03b1, IL-6, and PGE2 levels. It suppressed the MAPK\/NF-\u03baB signaling pathway by inhibiting the phosphorylation of ERK, JNK, I\u03baB\u03b1, and p65 and downregulating iNOS and COX-2 expression. Transcriptomic and docking studies confirmed that 2 targets key regulators and stably binds to the active pockets of TPL2 and NF-\u03baB p65. In vivo, 1 and 2 reduced foot edema and inflammatory cytokines, with no acute toxicity observed.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03240","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:01:34Z","timestamp":1789030894000},"page":"11896-11902","source":"Crossref","is-referenced-by-count":0,"title":["Boereguasins\nA\u2013D, Cytochalasins from\n                    <i>Boeremia exigua<\/i>\n                    with\nDifferential MAPK\/NF-\u03baB Inhibition"],"prefix":"10.1021","volume":"28","author":[{"given":"Chun","family":"Tian","sequence":"first","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]},{"name":"Anhui University of Chinese Medicine , , ,","place":["Hefei, People\u2019s Republic of China, 230012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Bao","family":"Shi","sequence":"additional","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ma","sequence":"additional","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Lin","family":"Feng","sequence":"additional","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Ping","family":"Wei","sequence":"additional","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yu","family":"Han","sequence":"additional","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Lian","family":"Ai","sequence":"additional","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"South-Central Minzu University , , ,","place":["Wuhan, People\u2019s Republic of China, 430074"]},{"name":"Anhui University of Chinese Medicine , , ,","place":["Hefei, People\u2019s Republic of China, 230012"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"2026092510112335800_cit1","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1039\/b903913a","article-title":"The chemistry and biology\nof cytochalasans","volume":"27","author":"Scherlach","year":"2010","journal-title":"Nat. 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Eng."}],"container-title":["Organic Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.orglett.6c03240","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/orlef7\/article-pdf\/28\/38\/11896\/68467776\/acs.orglett.6c03240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/orlef7\/article-pdf\/28\/38\/11896\/68467776\/acs.orglett.6c03240.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:13:14Z","timestamp":1790345594000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/orlef7\/article\/28\/38\/11896\/5427473\/Boereguasins-A-D-Cytochalasins-from-Boeremia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":30,"journal-issue":{"issue":"38","published-online":{"date-parts":[[2026,9,10]]},"published-print":{"date-parts":[[2026,9,25]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.orglett.6c03240","relation":{},"ISSN":["1523-7060","1523-7052"],"issn-type":[{"value":"1523-7060","type":"print"},{"value":"1523-7052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}