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This operationally simple method affords largely excellent conversion to Dha\/\u0394Val containing peptide substrates. Such in situ generation of reactive alkene handles provides a powerful method for synthesizing post-translational mimetics, as demonstrated by the facile conjugation of thiol-bearing cargos (drugs, lipids, fluorophores, glutathione) under mild conditions in the same pot or with purified Dha-peptide, highlighting the method\u2019s potential in peptide engineering.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03243","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:01:57Z","timestamp":1790013717000},"page":"12218-12223","source":"Crossref","is-referenced-by-count":0,"title":["Leveraging Iodomethylboronic\nEster Reactivity to Access\nLate-Stage Dehydroalanine and Dehydrovaline onto Peptides in Water"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0091-3443","authenticated-orcid":true,"given":"Sagnika","family":"Ghosh","sequence":"first","affiliation":[{"name":"Indian Institute of Technology Ropar , , Baraphool , , ,","place":["Rupnagar, Punjab, India, 140001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-3303","authenticated-orcid":true,"given":"Saurav","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Ropar , , Baraphool , , ,","place":["Rupnagar, Punjab, India, 140001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3221-0315","authenticated-orcid":true,"given":"Anupam","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Ropar , , Baraphool , , ,","place":["Rupnagar, Punjab, India, 140001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2026100208373858800_cit1","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1021\/acs.biochem.7b00536","article-title":"Residue-Specific Peptide Modification:\nA Chemist\u2019s Guide","volume":"56","author":"deGruyter","year":"2017","journal-title":"Biochemistry"},{"key":"2026100208373858800_cit2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cbpa.2014.10.021","article-title":"Covalent Protein\nModification: The Current Landscape\nof Residue-Specific Electrophiles","volume":"24","author":"Shannon","year":"2015","journal-title":"Curr. 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